The Estrogen-Induced Effects on Myometrium Are the Result of Activation of Two Different Receptor Types: GPER and ERα

GPER (G protein coupled estrogen receptor 1), a particular estrogen binding site, is ubiquitously present in human tissues, but its precise physiological role is still very disputed. GPER is associated with normal and abnormal estrogen-dependent proliferations in female tissues and is involved in ge...

Descripción completa

Detalles Bibliográficos
Autores principales: TICA, O.S., COMANESCU, A., BOGDAN, M., ALEXANDRU, D.O., TICA, A.A., CIUREA, T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical University Publishing House Craiova 2015
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246995/
https://www.ncbi.nlm.nih.gov/pubmed/30534424
http://dx.doi.org/10.12865/CHSJ.41.03.03
Descripción
Sumario:GPER (G protein coupled estrogen receptor 1), a particular estrogen binding site, is ubiquitously present in human tissues, but its precise physiological role is still very disputed. GPER is associated with normal and abnormal estrogen-dependent proliferations in female tissues and is involved in generation of rapid estrogenic answers. A very important fact is that GPER-induced genomic effects are additive to those mediated by “classic” estrogen receptors, but regarding the rapid effects, as we prove in this study, these can be significant different or even antagonistic.

Ejemplares similares