The Estrogen-Induced Effects on Myometrium Are the Result of Activation of Two Different Receptor Types: GPER and ERα

GPER (G protein coupled estrogen receptor 1), a particular estrogen binding site, is ubiquitously present in human tissues, but its precise physiological role is still very disputed. GPER is associated with normal and abnormal estrogen-dependent proliferations in female tissues and is involved in ge...

Descripción completa

Detalles Bibliográficos
Autores principales: TICA, O.S., COMANESCU, A., BOGDAN, M., ALEXANDRU, D.O., TICA, A.A., CIUREA, T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical University Publishing House Craiova 2015
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246995/
https://www.ncbi.nlm.nih.gov/pubmed/30534424
http://dx.doi.org/10.12865/CHSJ.41.03.03
_version_ 1783372419931570176
author TICA, O.S.
COMANESCU, A.
BOGDAN, M.
ALEXANDRU, D.O.
TICA, A.A.
CIUREA, T.
author_facet TICA, O.S.
COMANESCU, A.
BOGDAN, M.
ALEXANDRU, D.O.
TICA, A.A.
CIUREA, T.
author_sort TICA, O.S.
collection PubMed
description GPER (G protein coupled estrogen receptor 1), a particular estrogen binding site, is ubiquitously present in human tissues, but its precise physiological role is still very disputed. GPER is associated with normal and abnormal estrogen-dependent proliferations in female tissues and is involved in generation of rapid estrogenic answers. A very important fact is that GPER-induced genomic effects are additive to those mediated by “classic” estrogen receptors, but regarding the rapid effects, as we prove in this study, these can be significant different or even antagonistic.
format Online
Article
Text
id pubmed-6246995
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Medical University Publishing House Craiova
record_format MEDLINE/PubMed
spelling pubmed-62469952018-12-10 The Estrogen-Induced Effects on Myometrium Are the Result of Activation of Two Different Receptor Types: GPER and ERα TICA, O.S. COMANESCU, A. BOGDAN, M. ALEXANDRU, D.O. TICA, A.A. CIUREA, T. Curr Health Sci J Original Paper GPER (G protein coupled estrogen receptor 1), a particular estrogen binding site, is ubiquitously present in human tissues, but its precise physiological role is still very disputed. GPER is associated with normal and abnormal estrogen-dependent proliferations in female tissues and is involved in generation of rapid estrogenic answers. A very important fact is that GPER-induced genomic effects are additive to those mediated by “classic” estrogen receptors, but regarding the rapid effects, as we prove in this study, these can be significant different or even antagonistic. Medical University Publishing House Craiova 2015 2015-01-29 /pmc/articles/PMC6246995/ /pubmed/30534424 http://dx.doi.org/10.12865/CHSJ.41.03.03 Text en Copyright © 2015, Medical University Publishing House Craiova http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
spellingShingle Original Paper
TICA, O.S.
COMANESCU, A.
BOGDAN, M.
ALEXANDRU, D.O.
TICA, A.A.
CIUREA, T.
The Estrogen-Induced Effects on Myometrium Are the Result of Activation of Two Different Receptor Types: GPER and ERα
title The Estrogen-Induced Effects on Myometrium Are the Result of Activation of Two Different Receptor Types: GPER and ERα
title_full The Estrogen-Induced Effects on Myometrium Are the Result of Activation of Two Different Receptor Types: GPER and ERα
title_fullStr The Estrogen-Induced Effects on Myometrium Are the Result of Activation of Two Different Receptor Types: GPER and ERα
title_full_unstemmed The Estrogen-Induced Effects on Myometrium Are the Result of Activation of Two Different Receptor Types: GPER and ERα
title_short The Estrogen-Induced Effects on Myometrium Are the Result of Activation of Two Different Receptor Types: GPER and ERα
title_sort estrogen-induced effects on myometrium are the result of activation of two different receptor types: gper and erα
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246995/
https://www.ncbi.nlm.nih.gov/pubmed/30534424
http://dx.doi.org/10.12865/CHSJ.41.03.03
work_keys_str_mv AT ticaos theestrogeninducedeffectsonmyometriumaretheresultofactivationoftwodifferentreceptortypesgperandera
AT comanescua theestrogeninducedeffectsonmyometriumaretheresultofactivationoftwodifferentreceptortypesgperandera
AT bogdanm theestrogeninducedeffectsonmyometriumaretheresultofactivationoftwodifferentreceptortypesgperandera
AT alexandrudo theestrogeninducedeffectsonmyometriumaretheresultofactivationoftwodifferentreceptortypesgperandera
AT ticaaa theestrogeninducedeffectsonmyometriumaretheresultofactivationoftwodifferentreceptortypesgperandera
AT ciureat theestrogeninducedeffectsonmyometriumaretheresultofactivationoftwodifferentreceptortypesgperandera
AT ticaos estrogeninducedeffectsonmyometriumaretheresultofactivationoftwodifferentreceptortypesgperandera
AT comanescua estrogeninducedeffectsonmyometriumaretheresultofactivationoftwodifferentreceptortypesgperandera
AT bogdanm estrogeninducedeffectsonmyometriumaretheresultofactivationoftwodifferentreceptortypesgperandera
AT alexandrudo estrogeninducedeffectsonmyometriumaretheresultofactivationoftwodifferentreceptortypesgperandera
AT ticaaa estrogeninducedeffectsonmyometriumaretheresultofactivationoftwodifferentreceptortypesgperandera
AT ciureat estrogeninducedeffectsonmyometriumaretheresultofactivationoftwodifferentreceptortypesgperandera

Ejemplares similares