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非小细胞肺癌中Ang-2相关研究进展
Non-small cell lung cancer (NSCLC) is one of the malignant tumors with highest mortality in the world, it is still a difficult problem in clinical field. Its occurrence and development are closely associated with tumor angiogenesis. Angiopoietin-2 (Ang-2) is an important angiogenesis factor that has...
Formato: | Online Artículo Texto |
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Lenguaje: | English |
Publicado: |
中国肺癌杂志编辑部
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247002/ https://www.ncbi.nlm.nih.gov/pubmed/30454550 http://dx.doi.org/10.3779/j.issn.1009-3419.2018.11.09 |
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collection | PubMed |
description | Non-small cell lung cancer (NSCLC) is one of the malignant tumors with highest mortality in the world, it is still a difficult problem in clinical field. Its occurrence and development are closely associated with tumor angiogenesis. Angiopoietin-2 (Ang-2) is an important angiogenesis factor that has involved in many researches and it has been confirmed that the expression of Ang-2 is significantly up-regulated in tissues and blood of NSCLC. Meanwhile, Ang-2 is related to malignant biological behavior of cancer cells, making it a potential biological marker for the diagnosis and prognosis of NSCLC. At present, researches on Ang-2 how to promote the progression of NSCLC around the world are focused on Ang-2 regulating the proliferation, invasion, and metastasis of NSCLC. This paper summarized and estimated the studies and literature reports of regulatory mechanisms of Ang-2 in NSCLC, hopefully it could help looking for targeted drug treatment of Ang-2 in the future. |
format | Online Article Text |
id | pubmed-6247002 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | 中国肺癌杂志编辑部 |
record_format | MEDLINE/PubMed |
spelling | pubmed-62470022018-12-05 非小细胞肺癌中Ang-2相关研究进展 Zhongguo Fei Ai Za Zhi 综述 Non-small cell lung cancer (NSCLC) is one of the malignant tumors with highest mortality in the world, it is still a difficult problem in clinical field. Its occurrence and development are closely associated with tumor angiogenesis. Angiopoietin-2 (Ang-2) is an important angiogenesis factor that has involved in many researches and it has been confirmed that the expression of Ang-2 is significantly up-regulated in tissues and blood of NSCLC. Meanwhile, Ang-2 is related to malignant biological behavior of cancer cells, making it a potential biological marker for the diagnosis and prognosis of NSCLC. At present, researches on Ang-2 how to promote the progression of NSCLC around the world are focused on Ang-2 regulating the proliferation, invasion, and metastasis of NSCLC. This paper summarized and estimated the studies and literature reports of regulatory mechanisms of Ang-2 in NSCLC, hopefully it could help looking for targeted drug treatment of Ang-2 in the future. 中国肺癌杂志编辑部 2018-11-20 /pmc/articles/PMC6247002/ /pubmed/30454550 http://dx.doi.org/10.3779/j.issn.1009-3419.2018.11.09 Text en 版权所有©《中国肺癌杂志》编辑部2018 https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 3.0) License. See: https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | 综述 非小细胞肺癌中Ang-2相关研究进展 |
title | 非小细胞肺癌中Ang-2相关研究进展 |
title_full | 非小细胞肺癌中Ang-2相关研究进展 |
title_fullStr | 非小细胞肺癌中Ang-2相关研究进展 |
title_full_unstemmed | 非小细胞肺癌中Ang-2相关研究进展 |
title_short | 非小细胞肺癌中Ang-2相关研究进展 |
title_sort | 非小细胞肺癌中ang-2相关研究进展 |
topic | 综述 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247002/ https://www.ncbi.nlm.nih.gov/pubmed/30454550 http://dx.doi.org/10.3779/j.issn.1009-3419.2018.11.09 |
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