Cargando…
Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases
Asprosin is a white adipose tissue-derived hormone that increases abnormally in mammals with insulin resistance. However, the role of asprosin in polycystic ovary syndrome (PCOS), a disease partly characterized by insulin resistance, and its potential connection with type 2 diabetes mellitus (T2DM)...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247534/ https://www.ncbi.nlm.nih.gov/pubmed/30524197 http://dx.doi.org/10.1155/2018/7375294 |
_version_ | 1783372495770877952 |
---|---|
author | Li, Xing Liao, Mingyu Shen, Rufei Zhang, Linlin Hu, Hua Wu, Jun Wang, Xiuli Qu, Hua Guo, Shaodong Long, Min Zheng, Hongting |
author_facet | Li, Xing Liao, Mingyu Shen, Rufei Zhang, Linlin Hu, Hua Wu, Jun Wang, Xiuli Qu, Hua Guo, Shaodong Long, Min Zheng, Hongting |
author_sort | Li, Xing |
collection | PubMed |
description | Asprosin is a white adipose tissue-derived hormone that increases abnormally in mammals with insulin resistance. However, the role of asprosin in polycystic ovary syndrome (PCOS), a disease partly characterized by insulin resistance, and its potential connection with type 2 diabetes mellitus (T2DM) and PCOS has not been thoroughly elucidated to date. To investigate the association of asprosin with metabolic profiles, sex-related hormones, or inflammation in females with T2DM or PCOS, plasma asprosin and metabolic indicators were measured in 66 healthy females, 53 female patients with T2DM, and 41 patients with PCOS. Spearman's correlation analysis and binary logistic regression analysis models were used. Plasma asprosin was significantly higher in T2DM females than in healthy subjects (P < 0.001) and was positively correlated with fasting blood glucose (FBG), hemoglobin A1c (HbA1c), and HOMA-IR (P < 0.05). Asprosin in PCOS subjects was also higher than in healthy subjects (P < 0.001) but lower than in T2DM subjects (P < 0.05), and it was positively correlated with FBG, HbA1c, HOMA-IR, LDL-c, APOB, APOE, and testosterone (P < 0.05). The BMI-categorized subgroups of PCOS subjects also showed correlations of asprosin with metabolic profiles and sex-related hormones. Binary logistic regression analysis revealed that plasma asprosin level acted as an independent risk factor for T2DM or PCOS. These findings suggest the correlation of plasma asprosin level with glucose metabolism, lipid metabolism, sex-related hormones, and inflammation in females, supporting asprosin as a potential predictive factor for females with metabolic-related diseases. This trial is registered with ChiCTR-ROC-17010719. |
format | Online Article Text |
id | pubmed-6247534 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-62475342018-12-06 Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases Li, Xing Liao, Mingyu Shen, Rufei Zhang, Linlin Hu, Hua Wu, Jun Wang, Xiuli Qu, Hua Guo, Shaodong Long, Min Zheng, Hongting Mediators Inflamm Clinical Study Asprosin is a white adipose tissue-derived hormone that increases abnormally in mammals with insulin resistance. However, the role of asprosin in polycystic ovary syndrome (PCOS), a disease partly characterized by insulin resistance, and its potential connection with type 2 diabetes mellitus (T2DM) and PCOS has not been thoroughly elucidated to date. To investigate the association of asprosin with metabolic profiles, sex-related hormones, or inflammation in females with T2DM or PCOS, plasma asprosin and metabolic indicators were measured in 66 healthy females, 53 female patients with T2DM, and 41 patients with PCOS. Spearman's correlation analysis and binary logistic regression analysis models were used. Plasma asprosin was significantly higher in T2DM females than in healthy subjects (P < 0.001) and was positively correlated with fasting blood glucose (FBG), hemoglobin A1c (HbA1c), and HOMA-IR (P < 0.05). Asprosin in PCOS subjects was also higher than in healthy subjects (P < 0.001) but lower than in T2DM subjects (P < 0.05), and it was positively correlated with FBG, HbA1c, HOMA-IR, LDL-c, APOB, APOE, and testosterone (P < 0.05). The BMI-categorized subgroups of PCOS subjects also showed correlations of asprosin with metabolic profiles and sex-related hormones. Binary logistic regression analysis revealed that plasma asprosin level acted as an independent risk factor for T2DM or PCOS. These findings suggest the correlation of plasma asprosin level with glucose metabolism, lipid metabolism, sex-related hormones, and inflammation in females, supporting asprosin as a potential predictive factor for females with metabolic-related diseases. This trial is registered with ChiCTR-ROC-17010719. Hindawi 2018-11-06 /pmc/articles/PMC6247534/ /pubmed/30524197 http://dx.doi.org/10.1155/2018/7375294 Text en Copyright © 2018 Xing Li et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Li, Xing Liao, Mingyu Shen, Rufei Zhang, Linlin Hu, Hua Wu, Jun Wang, Xiuli Qu, Hua Guo, Shaodong Long, Min Zheng, Hongting Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases |
title | Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases |
title_full | Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases |
title_fullStr | Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases |
title_full_unstemmed | Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases |
title_short | Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases |
title_sort | plasma asprosin levels are associated with glucose metabolism, lipid, and sex hormone profiles in females with metabolic-related diseases |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247534/ https://www.ncbi.nlm.nih.gov/pubmed/30524197 http://dx.doi.org/10.1155/2018/7375294 |
work_keys_str_mv | AT lixing plasmaasprosinlevelsareassociatedwithglucosemetabolismlipidandsexhormoneprofilesinfemaleswithmetabolicrelateddiseases AT liaomingyu plasmaasprosinlevelsareassociatedwithglucosemetabolismlipidandsexhormoneprofilesinfemaleswithmetabolicrelateddiseases AT shenrufei plasmaasprosinlevelsareassociatedwithglucosemetabolismlipidandsexhormoneprofilesinfemaleswithmetabolicrelateddiseases AT zhanglinlin plasmaasprosinlevelsareassociatedwithglucosemetabolismlipidandsexhormoneprofilesinfemaleswithmetabolicrelateddiseases AT huhua plasmaasprosinlevelsareassociatedwithglucosemetabolismlipidandsexhormoneprofilesinfemaleswithmetabolicrelateddiseases AT wujun plasmaasprosinlevelsareassociatedwithglucosemetabolismlipidandsexhormoneprofilesinfemaleswithmetabolicrelateddiseases AT wangxiuli plasmaasprosinlevelsareassociatedwithglucosemetabolismlipidandsexhormoneprofilesinfemaleswithmetabolicrelateddiseases AT quhua plasmaasprosinlevelsareassociatedwithglucosemetabolismlipidandsexhormoneprofilesinfemaleswithmetabolicrelateddiseases AT guoshaodong plasmaasprosinlevelsareassociatedwithglucosemetabolismlipidandsexhormoneprofilesinfemaleswithmetabolicrelateddiseases AT longmin plasmaasprosinlevelsareassociatedwithglucosemetabolismlipidandsexhormoneprofilesinfemaleswithmetabolicrelateddiseases AT zhenghongting plasmaasprosinlevelsareassociatedwithglucosemetabolismlipidandsexhormoneprofilesinfemaleswithmetabolicrelateddiseases |