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Predictive Score Model for Delayed Graft Function Based on Hypothermic Machine Perfusion Variables in Kidney Transplantation

BACKGROUND: Hypothermic machine perfusion (HMP) is being used more often in cardiac death kidney transplantation; however, the significance of assessing organ quality and predicting delayed graft function (DGF) by HMP parameters is still controversial. Therefore, we used a readily available HMP vari...

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Autores principales: Ding, Chen-Guang, Li, Yang, Tian, Xiao-Hui, Hu, Xiao-Jun, Tian, Pu-Xun, Ding, Xiao-Ming, Xiang, He-Li, Zheng, Jin, Xue, Wu-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247597/
https://www.ncbi.nlm.nih.gov/pubmed/30425191
http://dx.doi.org/10.4103/0366-6999.245278
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author Ding, Chen-Guang
Li, Yang
Tian, Xiao-Hui
Hu, Xiao-Jun
Tian, Pu-Xun
Ding, Xiao-Ming
Xiang, He-Li
Zheng, Jin
Xue, Wu-Jun
author_facet Ding, Chen-Guang
Li, Yang
Tian, Xiao-Hui
Hu, Xiao-Jun
Tian, Pu-Xun
Ding, Xiao-Ming
Xiang, He-Li
Zheng, Jin
Xue, Wu-Jun
author_sort Ding, Chen-Guang
collection PubMed
description BACKGROUND: Hypothermic machine perfusion (HMP) is being used more often in cardiac death kidney transplantation; however, the significance of assessing organ quality and predicting delayed graft function (DGF) by HMP parameters is still controversial. Therefore, we used a readily available HMP variable to design a scoring model that can identify the highest risk of DGF and provide the guidance and advice for organ allocation and DCD kidney assessment. METHODS: From September 1, 2012 to August 31, 2016, 366 qualified kidneys were randomly assigned to the development and validation cohorts in a 2:1 distribution. The HMP variables of the development cohort served as candidate univariate predictors for DGF. The independent predictors of DGF were identified by multivariate logistic regression analysis with a P < 0.05. According to the odds ratios (ORs) value, each HMP variable was assigned a weighted integer, and the sum of the integers indicated the total risk score for each kidney. The validation cohort was used to verify the accuracy and reliability of the scoring model. RESULTS: HMP duration (OR = 1.165, 95% confidence interval [CI ]: 1.008–1.360, P = 0.043), resistance (OR = 2.190, 95% CI: 1.032–10.20, P < 0.001), and flow rate (OR = 0.931, 95% CI: 0.894–0.967, P = 0.011) were the independent predictors of identified DGF. The HMP predictive score ranged from 0 to 14, and there was a clear increase in the incidence of DGF, from the low predictive score group to the very high predictive score group. We formed four increasingly serious risk categories (scores 0–3, 4–7, 8–11, and 12–14) according to the frequency associated with the different risk scores of DGF. The HMP predictive score indicates good discriminative power with a c-statistic of 0.706 in the validation cohort, and it had significantly better prediction value for DGF compared to both terminal flow (P = 0.012) and resistance (P = 0.006). CONCLUSION: The HMP predictive score is a good noninvasive tool for assessing the quality of DCD kidneys, and it is potentially useful for physicians in making optimal decisions about the organs donated.
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spelling pubmed-62475972018-12-10 Predictive Score Model for Delayed Graft Function Based on Hypothermic Machine Perfusion Variables in Kidney Transplantation Ding, Chen-Guang Li, Yang Tian, Xiao-Hui Hu, Xiao-Jun Tian, Pu-Xun Ding, Xiao-Ming Xiang, He-Li Zheng, Jin Xue, Wu-Jun Chin Med J (Engl) Original Article BACKGROUND: Hypothermic machine perfusion (HMP) is being used more often in cardiac death kidney transplantation; however, the significance of assessing organ quality and predicting delayed graft function (DGF) by HMP parameters is still controversial. Therefore, we used a readily available HMP variable to design a scoring model that can identify the highest risk of DGF and provide the guidance and advice for organ allocation and DCD kidney assessment. METHODS: From September 1, 2012 to August 31, 2016, 366 qualified kidneys were randomly assigned to the development and validation cohorts in a 2:1 distribution. The HMP variables of the development cohort served as candidate univariate predictors for DGF. The independent predictors of DGF were identified by multivariate logistic regression analysis with a P < 0.05. According to the odds ratios (ORs) value, each HMP variable was assigned a weighted integer, and the sum of the integers indicated the total risk score for each kidney. The validation cohort was used to verify the accuracy and reliability of the scoring model. RESULTS: HMP duration (OR = 1.165, 95% confidence interval [CI ]: 1.008–1.360, P = 0.043), resistance (OR = 2.190, 95% CI: 1.032–10.20, P < 0.001), and flow rate (OR = 0.931, 95% CI: 0.894–0.967, P = 0.011) were the independent predictors of identified DGF. The HMP predictive score ranged from 0 to 14, and there was a clear increase in the incidence of DGF, from the low predictive score group to the very high predictive score group. We formed four increasingly serious risk categories (scores 0–3, 4–7, 8–11, and 12–14) according to the frequency associated with the different risk scores of DGF. The HMP predictive score indicates good discriminative power with a c-statistic of 0.706 in the validation cohort, and it had significantly better prediction value for DGF compared to both terminal flow (P = 0.012) and resistance (P = 0.006). CONCLUSION: The HMP predictive score is a good noninvasive tool for assessing the quality of DCD kidneys, and it is potentially useful for physicians in making optimal decisions about the organs donated. Medknow Publications & Media Pvt Ltd 2018-11-20 /pmc/articles/PMC6247597/ /pubmed/30425191 http://dx.doi.org/10.4103/0366-6999.245278 Text en Copyright: © 2018 Chinese Medical Journal http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Ding, Chen-Guang
Li, Yang
Tian, Xiao-Hui
Hu, Xiao-Jun
Tian, Pu-Xun
Ding, Xiao-Ming
Xiang, He-Li
Zheng, Jin
Xue, Wu-Jun
Predictive Score Model for Delayed Graft Function Based on Hypothermic Machine Perfusion Variables in Kidney Transplantation
title Predictive Score Model for Delayed Graft Function Based on Hypothermic Machine Perfusion Variables in Kidney Transplantation
title_full Predictive Score Model for Delayed Graft Function Based on Hypothermic Machine Perfusion Variables in Kidney Transplantation
title_fullStr Predictive Score Model for Delayed Graft Function Based on Hypothermic Machine Perfusion Variables in Kidney Transplantation
title_full_unstemmed Predictive Score Model for Delayed Graft Function Based on Hypothermic Machine Perfusion Variables in Kidney Transplantation
title_short Predictive Score Model for Delayed Graft Function Based on Hypothermic Machine Perfusion Variables in Kidney Transplantation
title_sort predictive score model for delayed graft function based on hypothermic machine perfusion variables in kidney transplantation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247597/
https://www.ncbi.nlm.nih.gov/pubmed/30425191
http://dx.doi.org/10.4103/0366-6999.245278
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