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Anti-inflammatory Activity of Tocotrienols in Age-related Pathologies: A SASPected Involvement of Cellular Senescence
Tocotrienols (T3) have been shown to represent a very important part of the vitamin E family since they have opened new opportunities to prevent or treat a multitude of age-related chronic diseases. The beneficial effects of T3 include the amelioration of lipid profile, the promotion of Nrf2 mediate...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247629/ https://www.ncbi.nlm.nih.gov/pubmed/30479579 http://dx.doi.org/10.1186/s12575-018-0087-4 |
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author | Malavolta, Marco Pierpaoli, Elisa Giacconi, Robertina Basso, Andrea Cardelli, Maurizio Piacenza, Francesco Provinciali, Mauro |
author_facet | Malavolta, Marco Pierpaoli, Elisa Giacconi, Robertina Basso, Andrea Cardelli, Maurizio Piacenza, Francesco Provinciali, Mauro |
author_sort | Malavolta, Marco |
collection | PubMed |
description | Tocotrienols (T3) have been shown to represent a very important part of the vitamin E family since they have opened new opportunities to prevent or treat a multitude of age-related chronic diseases. The beneficial effects of T3 include the amelioration of lipid profile, the promotion of Nrf2 mediated cytoprotective activity and the suppression of inflammation. All these effects may be the consequence of the ability of T3 to target multiple pathways. We here propose that these effects may be the result of a single target of T3, namely senescent cells. Indeed, T3 may act by a direct suppression of the senescence-associated secretory phenotype (SASP) produced by senescent cells, mediated by inhibition of NF-kB and mTOR, or may potentially remove the origin of the SASP trough senolysis (selective death of senescent cells). Further studies addressed to investigate the impact of T3 on cellular senescence “in vitro” as well as in experimental models of age-related diseases “in vivo” are clearly encouraged. |
format | Online Article Text |
id | pubmed-6247629 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-62476292018-11-26 Anti-inflammatory Activity of Tocotrienols in Age-related Pathologies: A SASPected Involvement of Cellular Senescence Malavolta, Marco Pierpaoli, Elisa Giacconi, Robertina Basso, Andrea Cardelli, Maurizio Piacenza, Francesco Provinciali, Mauro Biol Proced Online Review Tocotrienols (T3) have been shown to represent a very important part of the vitamin E family since they have opened new opportunities to prevent or treat a multitude of age-related chronic diseases. The beneficial effects of T3 include the amelioration of lipid profile, the promotion of Nrf2 mediated cytoprotective activity and the suppression of inflammation. All these effects may be the consequence of the ability of T3 to target multiple pathways. We here propose that these effects may be the result of a single target of T3, namely senescent cells. Indeed, T3 may act by a direct suppression of the senescence-associated secretory phenotype (SASP) produced by senescent cells, mediated by inhibition of NF-kB and mTOR, or may potentially remove the origin of the SASP trough senolysis (selective death of senescent cells). Further studies addressed to investigate the impact of T3 on cellular senescence “in vitro” as well as in experimental models of age-related diseases “in vivo” are clearly encouraged. BioMed Central 2018-11-20 /pmc/articles/PMC6247629/ /pubmed/30479579 http://dx.doi.org/10.1186/s12575-018-0087-4 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Malavolta, Marco Pierpaoli, Elisa Giacconi, Robertina Basso, Andrea Cardelli, Maurizio Piacenza, Francesco Provinciali, Mauro Anti-inflammatory Activity of Tocotrienols in Age-related Pathologies: A SASPected Involvement of Cellular Senescence |
title | Anti-inflammatory Activity of Tocotrienols in Age-related Pathologies: A SASPected Involvement of Cellular Senescence |
title_full | Anti-inflammatory Activity of Tocotrienols in Age-related Pathologies: A SASPected Involvement of Cellular Senescence |
title_fullStr | Anti-inflammatory Activity of Tocotrienols in Age-related Pathologies: A SASPected Involvement of Cellular Senescence |
title_full_unstemmed | Anti-inflammatory Activity of Tocotrienols in Age-related Pathologies: A SASPected Involvement of Cellular Senescence |
title_short | Anti-inflammatory Activity of Tocotrienols in Age-related Pathologies: A SASPected Involvement of Cellular Senescence |
title_sort | anti-inflammatory activity of tocotrienols in age-related pathologies: a saspected involvement of cellular senescence |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247629/ https://www.ncbi.nlm.nih.gov/pubmed/30479579 http://dx.doi.org/10.1186/s12575-018-0087-4 |
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