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Palladium(ii)-catalyzed γ-selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids
A catalytic γ-selective syn-hydroarylation of alkenyl carbonyl compounds using arylboronic acids has been developed using a substrate directivity approach with a palladium(ii) catalyst. This method tolerates a wide range of functionalized (hetero)arylboronic acids and a variety of substitution patte...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247822/ https://www.ncbi.nlm.nih.gov/pubmed/30542583 http://dx.doi.org/10.1039/c8sc03081b |
| _version_ | 1783372556589334528 |
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| author | Matsuura, Rei Jankins, Tanner C. Hill, David E. Yang, Kin S. Gallego, Gary M. Yang, Shouliang He, Mingying Wang, Fen Marsters, Rohan P. McAlpine, Indrawan Engle, Keary M. |
| author_facet | Matsuura, Rei Jankins, Tanner C. Hill, David E. Yang, Kin S. Gallego, Gary M. Yang, Shouliang He, Mingying Wang, Fen Marsters, Rohan P. McAlpine, Indrawan Engle, Keary M. |
| author_sort | Matsuura, Rei |
| collection | PubMed |
| description | A catalytic γ-selective syn-hydroarylation of alkenyl carbonyl compounds using arylboronic acids has been developed using a substrate directivity approach with a palladium(ii) catalyst. This method tolerates a wide range of functionalized (hetero)arylboronic acids and a variety of substitution patterns on the alkene. Preliminary mechanistic studies suggest that transmetalation is rate-limiting. |
| format | Online Article Text |
| id | pubmed-6247822 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Royal Society of Chemistry |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-62478222018-12-12 Palladium(ii)-catalyzed γ-selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids Matsuura, Rei Jankins, Tanner C. Hill, David E. Yang, Kin S. Gallego, Gary M. Yang, Shouliang He, Mingying Wang, Fen Marsters, Rohan P. McAlpine, Indrawan Engle, Keary M. Chem Sci Chemistry A catalytic γ-selective syn-hydroarylation of alkenyl carbonyl compounds using arylboronic acids has been developed using a substrate directivity approach with a palladium(ii) catalyst. This method tolerates a wide range of functionalized (hetero)arylboronic acids and a variety of substitution patterns on the alkene. Preliminary mechanistic studies suggest that transmetalation is rate-limiting. Royal Society of Chemistry 2018-09-06 /pmc/articles/PMC6247822/ /pubmed/30542583 http://dx.doi.org/10.1039/c8sc03081b Text en This journal is © The Royal Society of Chemistry 2018 http://creativecommons.org/licenses/by-nc/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported Licence (CC BY-NC 3.0) |
| spellingShingle | Chemistry Matsuura, Rei Jankins, Tanner C. Hill, David E. Yang, Kin S. Gallego, Gary M. Yang, Shouliang He, Mingying Wang, Fen Marsters, Rohan P. McAlpine, Indrawan Engle, Keary M. Palladium(ii)-catalyzed γ-selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids |
| title | Palladium(ii)-catalyzed γ-selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids
|
| title_full | Palladium(ii)-catalyzed γ-selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids
|
| title_fullStr | Palladium(ii)-catalyzed γ-selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids
|
| title_full_unstemmed | Palladium(ii)-catalyzed γ-selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids
|
| title_short | Palladium(ii)-catalyzed γ-selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids
|
| title_sort | palladium(ii)-catalyzed γ-selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids |
| topic | Chemistry |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247822/ https://www.ncbi.nlm.nih.gov/pubmed/30542583 http://dx.doi.org/10.1039/c8sc03081b |
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