Cargando…

Nextstrain: real-time tracking of pathogen evolution

SUMMARY: Understanding the spread and evolution of pathogens is important for effective public health measures and surveillance. Nextstrain consists of a database of viral genomes, a bioinformatics pipeline for phylodynamics analysis, and an interactive visualization platform. Together these present...

Descripción completa

Detalles Bibliográficos
Autores principales: Hadfield, James, Megill, Colin, Bell, Sidney M, Huddleston, John, Potter, Barney, Callender, Charlton, Sagulenko, Pavel, Bedford, Trevor, Neher, Richard A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247931/
https://www.ncbi.nlm.nih.gov/pubmed/29790939
http://dx.doi.org/10.1093/bioinformatics/bty407
_version_ 1783372566699704320
author Hadfield, James
Megill, Colin
Bell, Sidney M
Huddleston, John
Potter, Barney
Callender, Charlton
Sagulenko, Pavel
Bedford, Trevor
Neher, Richard A
author_facet Hadfield, James
Megill, Colin
Bell, Sidney M
Huddleston, John
Potter, Barney
Callender, Charlton
Sagulenko, Pavel
Bedford, Trevor
Neher, Richard A
author_sort Hadfield, James
collection PubMed
description SUMMARY: Understanding the spread and evolution of pathogens is important for effective public health measures and surveillance. Nextstrain consists of a database of viral genomes, a bioinformatics pipeline for phylodynamics analysis, and an interactive visualization platform. Together these present a real-time view into the evolution and spread of a range of viral pathogens of high public health importance. The visualization integrates sequence data with other data types such as geographic information, serology, or host species. Nextstrain compiles our current understanding into a single accessible location, open to health professionals, epidemiologists, virologists and the public alike. AVAILABILITY AND IMPLEMENTATION: All code (predominantly JavaScript and Python) is freely available from github.com/nextstrain and the web-application is available at nextstrain.org.
format Online
Article
Text
id pubmed-6247931
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-62479312018-11-28 Nextstrain: real-time tracking of pathogen evolution Hadfield, James Megill, Colin Bell, Sidney M Huddleston, John Potter, Barney Callender, Charlton Sagulenko, Pavel Bedford, Trevor Neher, Richard A Bioinformatics Applications Notes SUMMARY: Understanding the spread and evolution of pathogens is important for effective public health measures and surveillance. Nextstrain consists of a database of viral genomes, a bioinformatics pipeline for phylodynamics analysis, and an interactive visualization platform. Together these present a real-time view into the evolution and spread of a range of viral pathogens of high public health importance. The visualization integrates sequence data with other data types such as geographic information, serology, or host species. Nextstrain compiles our current understanding into a single accessible location, open to health professionals, epidemiologists, virologists and the public alike. AVAILABILITY AND IMPLEMENTATION: All code (predominantly JavaScript and Python) is freely available from github.com/nextstrain and the web-application is available at nextstrain.org. Oxford University Press 2018-12-01 2018-05-22 /pmc/articles/PMC6247931/ /pubmed/29790939 http://dx.doi.org/10.1093/bioinformatics/bty407 Text en © The Author(s) 2018. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Applications Notes
Hadfield, James
Megill, Colin
Bell, Sidney M
Huddleston, John
Potter, Barney
Callender, Charlton
Sagulenko, Pavel
Bedford, Trevor
Neher, Richard A
Nextstrain: real-time tracking of pathogen evolution
title Nextstrain: real-time tracking of pathogen evolution
title_full Nextstrain: real-time tracking of pathogen evolution
title_fullStr Nextstrain: real-time tracking of pathogen evolution
title_full_unstemmed Nextstrain: real-time tracking of pathogen evolution
title_short Nextstrain: real-time tracking of pathogen evolution
title_sort nextstrain: real-time tracking of pathogen evolution
topic Applications Notes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247931/
https://www.ncbi.nlm.nih.gov/pubmed/29790939
http://dx.doi.org/10.1093/bioinformatics/bty407
work_keys_str_mv AT hadfieldjames nextstrainrealtimetrackingofpathogenevolution
AT megillcolin nextstrainrealtimetrackingofpathogenevolution
AT bellsidneym nextstrainrealtimetrackingofpathogenevolution
AT huddlestonjohn nextstrainrealtimetrackingofpathogenevolution
AT potterbarney nextstrainrealtimetrackingofpathogenevolution
AT callendercharlton nextstrainrealtimetrackingofpathogenevolution
AT sagulenkopavel nextstrainrealtimetrackingofpathogenevolution
AT bedfordtrevor nextstrainrealtimetrackingofpathogenevolution
AT neherricharda nextstrainrealtimetrackingofpathogenevolution