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Clinical Analysis of Classification and Prognosis of Ischemia-Type Biliary Lesions After Liver Transplantation

BACKGROUND: The aim of this study was to classify ischemia-type biliary lesions after liver transplantation according to their imaging findings and severity of clinical manifestations and to analyze the relationship between such classification and prognosis. MATERIAL/METHODS: We collected clinical d...

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Autores principales: Shi, Rui, Liu, Tong, Liu, Zirong, Zhang, Yamin, Shen, Zhongyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248068/
https://www.ncbi.nlm.nih.gov/pubmed/29555897
http://dx.doi.org/10.12659/AOT.907240
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author Shi, Rui
Liu, Tong
Liu, Zirong
Zhang, Yamin
Shen, Zhongyang
author_facet Shi, Rui
Liu, Tong
Liu, Zirong
Zhang, Yamin
Shen, Zhongyang
author_sort Shi, Rui
collection PubMed
description BACKGROUND: The aim of this study was to classify ischemia-type biliary lesions after liver transplantation according to their imaging findings and severity of clinical manifestations and to analyze the relationship between such classification and prognosis. MATERIAL/METHODS: We collected clinical data of patients with ischemia-type biliary lesions (ITBL) after liver transplantation in the Organ Transplantation Center, the First Central Hospital of Tianjin, from August 2012 to July 2013; all patients were classified according to their imaging findings and relevant clinical data to analyze the relationship between their classification and prognosis. RESULTS: The mean postoperative survival time, as well as the 1-, 3-, and 5-year survival rate, in Group ITBL showed statistical significance when compared with those in Group NITBL (log rank=12.13, P<0.001), but the mean postoperative survival times among the mild, moderate, and severe ITBL cases showed no statistical significance. The incidence rates of 1-, 3-, and 5-year adverse prognosis in Group ITBL showed statistical significance when compared with Group NITBL with <2% patients who had anastomotic biliary obstruction (log rank=277.06, P<0.001), among which the difference in the incidence rate of adverse prognosis between severe and moderate ITBL cases showed no statistical significance. The difference in the incidence rate of adverse prognosis between mild and moderate ITBL cases showed statistical significance (log rank=6.01, P=0.014), and the difference in the incidence rate of adverse prognosis between mild and severe ITBL cases showed statistical significance (log rank=10.98, P=0.001). CONCLUSIONS: ITBL classification based on the severity of biliary imaging and bilirubin level can predict the prognosis of ITBL.
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spelling pubmed-62480682018-11-28 Clinical Analysis of Classification and Prognosis of Ischemia-Type Biliary Lesions After Liver Transplantation Shi, Rui Liu, Tong Liu, Zirong Zhang, Yamin Shen, Zhongyang Ann Transplant Original Paper BACKGROUND: The aim of this study was to classify ischemia-type biliary lesions after liver transplantation according to their imaging findings and severity of clinical manifestations and to analyze the relationship between such classification and prognosis. MATERIAL/METHODS: We collected clinical data of patients with ischemia-type biliary lesions (ITBL) after liver transplantation in the Organ Transplantation Center, the First Central Hospital of Tianjin, from August 2012 to July 2013; all patients were classified according to their imaging findings and relevant clinical data to analyze the relationship between their classification and prognosis. RESULTS: The mean postoperative survival time, as well as the 1-, 3-, and 5-year survival rate, in Group ITBL showed statistical significance when compared with those in Group NITBL (log rank=12.13, P<0.001), but the mean postoperative survival times among the mild, moderate, and severe ITBL cases showed no statistical significance. The incidence rates of 1-, 3-, and 5-year adverse prognosis in Group ITBL showed statistical significance when compared with Group NITBL with <2% patients who had anastomotic biliary obstruction (log rank=277.06, P<0.001), among which the difference in the incidence rate of adverse prognosis between severe and moderate ITBL cases showed no statistical significance. The difference in the incidence rate of adverse prognosis between mild and moderate ITBL cases showed statistical significance (log rank=6.01, P=0.014), and the difference in the incidence rate of adverse prognosis between mild and severe ITBL cases showed statistical significance (log rank=10.98, P=0.001). CONCLUSIONS: ITBL classification based on the severity of biliary imaging and bilirubin level can predict the prognosis of ITBL. International Scientific Literature, Inc. 2018-03-20 /pmc/articles/PMC6248068/ /pubmed/29555897 http://dx.doi.org/10.12659/AOT.907240 Text en © Ann Transplant, 2018 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Original Paper
Shi, Rui
Liu, Tong
Liu, Zirong
Zhang, Yamin
Shen, Zhongyang
Clinical Analysis of Classification and Prognosis of Ischemia-Type Biliary Lesions After Liver Transplantation
title Clinical Analysis of Classification and Prognosis of Ischemia-Type Biliary Lesions After Liver Transplantation
title_full Clinical Analysis of Classification and Prognosis of Ischemia-Type Biliary Lesions After Liver Transplantation
title_fullStr Clinical Analysis of Classification and Prognosis of Ischemia-Type Biliary Lesions After Liver Transplantation
title_full_unstemmed Clinical Analysis of Classification and Prognosis of Ischemia-Type Biliary Lesions After Liver Transplantation
title_short Clinical Analysis of Classification and Prognosis of Ischemia-Type Biliary Lesions After Liver Transplantation
title_sort clinical analysis of classification and prognosis of ischemia-type biliary lesions after liver transplantation
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248068/
https://www.ncbi.nlm.nih.gov/pubmed/29555897
http://dx.doi.org/10.12659/AOT.907240
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