Cargando…

Perioperative Telemetric Monitoring in Pig-to-Baboon Heterotopic Thoracic Cardiac Xenotransplantation

BACKGROUND: Perioperative monitoring and hemodynamic management after heterotopic thoracic cardiac xenotransplantation is challenging due to 2 independently beating hearts. Telemetry allows continuous monitoring of hemodynamic parameters of both the donor and recipient hearts. We describe our experi...

Descripción completa

Detalles Bibliográficos
Autores principales: Längin, Matthias, Panelli, Alessandro, Reichart, Bruno, Kind, Alexander, Brenner, Paolo, Mayr, Tanja, Abicht, Jan-Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248073/
https://www.ncbi.nlm.nih.gov/pubmed/30026460
http://dx.doi.org/10.12659/AOT.909522
_version_ 1783372593350311936
author Längin, Matthias
Panelli, Alessandro
Reichart, Bruno
Kind, Alexander
Brenner, Paolo
Mayr, Tanja
Abicht, Jan-Michael
author_facet Längin, Matthias
Panelli, Alessandro
Reichart, Bruno
Kind, Alexander
Brenner, Paolo
Mayr, Tanja
Abicht, Jan-Michael
author_sort Längin, Matthias
collection PubMed
description BACKGROUND: Perioperative monitoring and hemodynamic management after heterotopic thoracic cardiac xenotransplantation is challenging due to 2 independently beating hearts. Telemetry allows continuous monitoring of hemodynamic parameters of both the donor and recipient hearts. We describe our experience and report on the validity of a telemetric system during and after surgery. MATERIAL/METHODS: Wireless telemetry transmitters were implanted in 3 baboons receiving porcine donor hearts. Left ventricular pressure and ECG were assessed from the donor heart, whereas aortic pressure and temperature were assessed from the recipient. Telemetric data were validated with invasive blood pressure measurements. RESULTS: Telemetric blood pressure was lower than invasive blood pressure. Intraoperatively, the probe in the graft’s left ventricle measured negative end-diastolic pressures. Telemetry allowed simple discrimination between donor’s and recipient’s heart rates. Body temperature was underestimated by telemetry. Telemetric monitoring facilitates recognition of graft arrhythmias and volume demand. CONCLUSIONS: In heterotopic thoracic cardiac xenotransplantation, telemetric implants are useful tools to continuously monitor the animals’ hemodynamic parameters and to discriminate donor and recipient organs. Accuracy is sufficient for systemic pressure measurement, but perioperative use of left ventricular end-diastolic pressure as a surrogate parameter for graft function is not advisable. Temperature measurements by telemetry do not reflect body core temperature.
format Online
Article
Text
id pubmed-6248073
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher International Scientific Literature, Inc.
record_format MEDLINE/PubMed
spelling pubmed-62480732018-11-28 Perioperative Telemetric Monitoring in Pig-to-Baboon Heterotopic Thoracic Cardiac Xenotransplantation Längin, Matthias Panelli, Alessandro Reichart, Bruno Kind, Alexander Brenner, Paolo Mayr, Tanja Abicht, Jan-Michael Ann Transplant Original Paper BACKGROUND: Perioperative monitoring and hemodynamic management after heterotopic thoracic cardiac xenotransplantation is challenging due to 2 independently beating hearts. Telemetry allows continuous monitoring of hemodynamic parameters of both the donor and recipient hearts. We describe our experience and report on the validity of a telemetric system during and after surgery. MATERIAL/METHODS: Wireless telemetry transmitters were implanted in 3 baboons receiving porcine donor hearts. Left ventricular pressure and ECG were assessed from the donor heart, whereas aortic pressure and temperature were assessed from the recipient. Telemetric data were validated with invasive blood pressure measurements. RESULTS: Telemetric blood pressure was lower than invasive blood pressure. Intraoperatively, the probe in the graft’s left ventricle measured negative end-diastolic pressures. Telemetry allowed simple discrimination between donor’s and recipient’s heart rates. Body temperature was underestimated by telemetry. Telemetric monitoring facilitates recognition of graft arrhythmias and volume demand. CONCLUSIONS: In heterotopic thoracic cardiac xenotransplantation, telemetric implants are useful tools to continuously monitor the animals’ hemodynamic parameters and to discriminate donor and recipient organs. Accuracy is sufficient for systemic pressure measurement, but perioperative use of left ventricular end-diastolic pressure as a surrogate parameter for graft function is not advisable. Temperature measurements by telemetry do not reflect body core temperature. International Scientific Literature, Inc. 2018-07-20 /pmc/articles/PMC6248073/ /pubmed/30026460 http://dx.doi.org/10.12659/AOT.909522 Text en © Ann Transplant, 2018 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Original Paper
Längin, Matthias
Panelli, Alessandro
Reichart, Bruno
Kind, Alexander
Brenner, Paolo
Mayr, Tanja
Abicht, Jan-Michael
Perioperative Telemetric Monitoring in Pig-to-Baboon Heterotopic Thoracic Cardiac Xenotransplantation
title Perioperative Telemetric Monitoring in Pig-to-Baboon Heterotopic Thoracic Cardiac Xenotransplantation
title_full Perioperative Telemetric Monitoring in Pig-to-Baboon Heterotopic Thoracic Cardiac Xenotransplantation
title_fullStr Perioperative Telemetric Monitoring in Pig-to-Baboon Heterotopic Thoracic Cardiac Xenotransplantation
title_full_unstemmed Perioperative Telemetric Monitoring in Pig-to-Baboon Heterotopic Thoracic Cardiac Xenotransplantation
title_short Perioperative Telemetric Monitoring in Pig-to-Baboon Heterotopic Thoracic Cardiac Xenotransplantation
title_sort perioperative telemetric monitoring in pig-to-baboon heterotopic thoracic cardiac xenotransplantation
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248073/
https://www.ncbi.nlm.nih.gov/pubmed/30026460
http://dx.doi.org/10.12659/AOT.909522
work_keys_str_mv AT langinmatthias perioperativetelemetricmonitoringinpigtobaboonheterotopicthoraciccardiacxenotransplantation
AT panellialessandro perioperativetelemetricmonitoringinpigtobaboonheterotopicthoraciccardiacxenotransplantation
AT reichartbruno perioperativetelemetricmonitoringinpigtobaboonheterotopicthoraciccardiacxenotransplantation
AT kindalexander perioperativetelemetricmonitoringinpigtobaboonheterotopicthoraciccardiacxenotransplantation
AT brennerpaolo perioperativetelemetricmonitoringinpigtobaboonheterotopicthoraciccardiacxenotransplantation
AT mayrtanja perioperativetelemetricmonitoringinpigtobaboonheterotopicthoraciccardiacxenotransplantation
AT abichtjanmichael perioperativetelemetricmonitoringinpigtobaboonheterotopicthoraciccardiacxenotransplantation