Valproic acid enhances the viability of random pattern skin flaps: involvement of enhancing angiogenesis and inhibiting oxidative stress and apoptosis

BACKGROUND: Random skin flaps are commonly applied during plastic surgery, but distal flap necrosis limits their clinical applications. Valproic acid (VPA), a histone deacetylase inhibitor and a traditional antiepileptic agent, may promote flap survival. MATERIALS AND METHODS: Sprague–Dawley rats we...

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Detalles Bibliográficos
Autores principales: Wu, Hongqiang, Ding, Jian, Wang, Lei, Lin, Jinti, Li, Shihen, Xiang, Guangheng, Jiang, Liangfu, Xu, Huazi, Gao, Weiyang, Zhou, Kailiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248271/
https://www.ncbi.nlm.nih.gov/pubmed/30510403
http://dx.doi.org/10.2147/DDDT.S186222

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