Treatment of Donor Rat Hearts Prior to Transplantation with FLIP (FADD-Like Interleukin Beta-Converting Enzyme (FLICE)-Like Inhibitory Protein) in Cardioplegic Solution Decreased Apoptosis at Thirty Minutes Post-transplantation and Decreased Total Tyrosine Phosphorylation Levels

BACKGROUND: Heart transplantation is a therapeutic option for patients with severe coronary artery disease or heart failure. One of the difficulties to overcome is the apoptosis of cardiomyocytes in the donor organ. To prevent apoptosis in the donor organ, we developed a fusion protein containing FL...

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Detalles Bibliográficos
Autores principales: Roset, Feliu, Ureña, Jesus M., Cotrufo, Tiziana, Carreras, José, de la Ossa, Pablo Pérez, Climent, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2018
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248286/
https://www.ncbi.nlm.nih.gov/pubmed/29483486
http://dx.doi.org/10.12659/AOT.903913

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