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The Evolution of Corneal Transplantation

BACKGROUND: The aim of this study was to investigate the evolution of surgical methods in and leading indications for corneal transplantation from 2005 to 2016. MATERIAL/METHODS: Data from the corneal graft waiting list and from all keratoplasties carried out between 2005 and 2016 at the University...

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Autores principales: Röck, Tobias, Landenberger, Johanna, Bramkamp, Matthias, Bartz-Schmidt, Karl Ulrich, Röck, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248302/
https://www.ncbi.nlm.nih.gov/pubmed/29242495
http://dx.doi.org/10.12659/AOT.905498
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author Röck, Tobias
Landenberger, Johanna
Bramkamp, Matthias
Bartz-Schmidt, Karl Ulrich
Röck, Daniel
author_facet Röck, Tobias
Landenberger, Johanna
Bramkamp, Matthias
Bartz-Schmidt, Karl Ulrich
Röck, Daniel
author_sort Röck, Tobias
collection PubMed
description BACKGROUND: The aim of this study was to investigate the evolution of surgical methods in and leading indications for corneal transplantation from 2005 to 2016. MATERIAL/METHODS: Data from the corneal graft waiting list and from all keratoplasties carried out between 2005 and 2016 at the University Eye Hospital Tübingen were retrospectively evaluated. RESULTS: A total of 1259 keratoplasties were performed between 2005 and 2016 at the University Eye Hospital Tübingen. The most common surgical indications for corneal transplantation were Fuchs endothelial corneal dystrophy (45.5%) and keratoconus (14.2%). The mean rate of corneal transplantations almost doubled from 71 keratoplasties per year in the first 6-year period to 139 keratoplasties per year in the second 6-year period (P=0.005). The number of penetrating keratoplasties remained similar. The number of Descemet membrane endothelial keratoplasties (DMEK) increased significantly from 2008 to 2016 (P<0.0001). One DMEK procedure was performed in 2008 (representing 1.4% of all transplantations), while 75 DMEK procedures were performed in 2016 (representing 60.5% of all transplantations) (P<0.0001). DMEK became the favored surgical method for endothelial disorders, exceeding penetrating keratoplasty in 2013. CONCLUSIONS: Our study shows evolutionary changes in preferred corneal transplantation techniques and leading indications for keratoplasty from 2005 to 2016. Since its introduction a decade ago, DMEK is currently the golden standard in the management of corneal endothelial dysfunction.
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spelling pubmed-62483022018-11-28 The Evolution of Corneal Transplantation Röck, Tobias Landenberger, Johanna Bramkamp, Matthias Bartz-Schmidt, Karl Ulrich Röck, Daniel Ann Transplant Original Paper BACKGROUND: The aim of this study was to investigate the evolution of surgical methods in and leading indications for corneal transplantation from 2005 to 2016. MATERIAL/METHODS: Data from the corneal graft waiting list and from all keratoplasties carried out between 2005 and 2016 at the University Eye Hospital Tübingen were retrospectively evaluated. RESULTS: A total of 1259 keratoplasties were performed between 2005 and 2016 at the University Eye Hospital Tübingen. The most common surgical indications for corneal transplantation were Fuchs endothelial corneal dystrophy (45.5%) and keratoconus (14.2%). The mean rate of corneal transplantations almost doubled from 71 keratoplasties per year in the first 6-year period to 139 keratoplasties per year in the second 6-year period (P=0.005). The number of penetrating keratoplasties remained similar. The number of Descemet membrane endothelial keratoplasties (DMEK) increased significantly from 2008 to 2016 (P<0.0001). One DMEK procedure was performed in 2008 (representing 1.4% of all transplantations), while 75 DMEK procedures were performed in 2016 (representing 60.5% of all transplantations) (P<0.0001). DMEK became the favored surgical method for endothelial disorders, exceeding penetrating keratoplasty in 2013. CONCLUSIONS: Our study shows evolutionary changes in preferred corneal transplantation techniques and leading indications for keratoplasty from 2005 to 2016. Since its introduction a decade ago, DMEK is currently the golden standard in the management of corneal endothelial dysfunction. International Scientific Literature, Inc. 2017-12-15 /pmc/articles/PMC6248302/ /pubmed/29242495 http://dx.doi.org/10.12659/AOT.905498 Text en © Ann Transplant, 2017 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Original Paper
Röck, Tobias
Landenberger, Johanna
Bramkamp, Matthias
Bartz-Schmidt, Karl Ulrich
Röck, Daniel
The Evolution of Corneal Transplantation
title The Evolution of Corneal Transplantation
title_full The Evolution of Corneal Transplantation
title_fullStr The Evolution of Corneal Transplantation
title_full_unstemmed The Evolution of Corneal Transplantation
title_short The Evolution of Corneal Transplantation
title_sort evolution of corneal transplantation
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248302/
https://www.ncbi.nlm.nih.gov/pubmed/29242495
http://dx.doi.org/10.12659/AOT.905498
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