Reversible Acute Kidney Injury Associated with Sildenafil Overdose

Sildenafil is a phosphodiesterase type 5 inhibitor that is approved to treat erectile dysfunction and pulmonary hypertension. Generally, sildenafil is safe, with mild side effects. Here, we report a case of acute kidney injury caused by a sildenafil overdose. A 67-year-old man took 400 mg of sildena...

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Detalles Bibliográficos
Autores principales: Liu, Baoqiong, Meng, Lingbin, Guan, Xuan, Gao, Lu, Trabin, Joshua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2018
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248710/
https://www.ncbi.nlm.nih.gov/pubmed/30473955
http://dx.doi.org/10.7759/cureus.3322
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author Liu, Baoqiong
Meng, Lingbin
Guan, Xuan
Gao, Lu
Trabin, Joshua
author_facet Liu, Baoqiong
Meng, Lingbin
Guan, Xuan
Gao, Lu
Trabin, Joshua
author_sort Liu, Baoqiong
collection PubMed
description Sildenafil is a phosphodiesterase type 5 inhibitor that is approved to treat erectile dysfunction and pulmonary hypertension. Generally, sildenafil is safe, with mild side effects. Here, we report a case of acute kidney injury caused by a sildenafil overdose. A 67-year-old man took 400 mg of sildenafil for erectile dysfunction. The patient was found to have acute kidney injury from acute tubular necrosis during hospitalization with a peak serum creatinine of 5.07 mg/dL though his renal function recovered with supportive care.
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spelling pubmed-62487102018-11-23 Reversible Acute Kidney Injury Associated with Sildenafil Overdose Liu, Baoqiong Meng, Lingbin Guan, Xuan Gao, Lu Trabin, Joshua Cureus Internal Medicine Sildenafil is a phosphodiesterase type 5 inhibitor that is approved to treat erectile dysfunction and pulmonary hypertension. Generally, sildenafil is safe, with mild side effects. Here, we report a case of acute kidney injury caused by a sildenafil overdose. A 67-year-old man took 400 mg of sildenafil for erectile dysfunction. The patient was found to have acute kidney injury from acute tubular necrosis during hospitalization with a peak serum creatinine of 5.07 mg/dL though his renal function recovered with supportive care. Cureus 2018-09-17 /pmc/articles/PMC6248710/ /pubmed/30473955 http://dx.doi.org/10.7759/cureus.3322 Text en Copyright © 2018, Liu et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Liu, Baoqiong
Meng, Lingbin
Guan, Xuan
Gao, Lu
Trabin, Joshua
Reversible Acute Kidney Injury Associated with Sildenafil Overdose
title Reversible Acute Kidney Injury Associated with Sildenafil Overdose
title_full Reversible Acute Kidney Injury Associated with Sildenafil Overdose
title_fullStr Reversible Acute Kidney Injury Associated with Sildenafil Overdose
title_full_unstemmed Reversible Acute Kidney Injury Associated with Sildenafil Overdose
title_short Reversible Acute Kidney Injury Associated with Sildenafil Overdose
title_sort reversible acute kidney injury associated with sildenafil overdose
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248710/
https://www.ncbi.nlm.nih.gov/pubmed/30473955
http://dx.doi.org/10.7759/cureus.3322
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AT gaolu reversibleacutekidneyinjuryassociatedwithsildenafiloverdose
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