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Salivary immunity and lower respiratory tract infections in non-elite marathon runners

RATIONALE: Respiratory infections are common after strenuous exercise, when salivary immunity may be altered. We aim to investigate changes in salivary immunity after a marathon and its relationship with lower respiratory tract infections (LRTI) in healthy non-elite marathon runners. METHODS: Forty...

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Autores principales: Cantó, Elisabet, Roca, Emma, Perea, Lidia, Rodrigo-Troyano, Ana, Suarez-Cuartin, Guillermo, Giner, Jordi, Feliu, Anna, Soria, Jose Manuel, Nescolarde, Lexa, Vidal, Silvia, Sibila, Oriol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248899/
https://www.ncbi.nlm.nih.gov/pubmed/30462646
http://dx.doi.org/10.1371/journal.pone.0206059
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author Cantó, Elisabet
Roca, Emma
Perea, Lidia
Rodrigo-Troyano, Ana
Suarez-Cuartin, Guillermo
Giner, Jordi
Feliu, Anna
Soria, Jose Manuel
Nescolarde, Lexa
Vidal, Silvia
Sibila, Oriol
author_facet Cantó, Elisabet
Roca, Emma
Perea, Lidia
Rodrigo-Troyano, Ana
Suarez-Cuartin, Guillermo
Giner, Jordi
Feliu, Anna
Soria, Jose Manuel
Nescolarde, Lexa
Vidal, Silvia
Sibila, Oriol
author_sort Cantó, Elisabet
collection PubMed
description RATIONALE: Respiratory infections are common after strenuous exercise, when salivary immunity may be altered. We aim to investigate changes in salivary immunity after a marathon and its relationship with lower respiratory tract infections (LRTI) in healthy non-elite marathon runners. METHODS: Forty seven healthy marathon runners (28 males and 19 females) who completed the 42.195 km of the 2016 Barcelona marathon were studied. Saliva and blood samples were collected the day before the marathon and two days after the end of the race. Salivary IgA, antimicrobial proteins (lactoferrin, lysozyme) and chemokines (Groα, Groβ, MCP-1) were determined using ELISA kits in saliva supernatant. Blood biochemistry and haemogram were analyzed in all participants. The presence of LRTI was considered in those runners who reported infectious lower respiratory tract symptoms during a minimum of 3 consecutive days in the 2 weeks after the race. RESULTS: Eight participants (17%) presented a LRTI during the 2 weeks of follow-up. Higher lysozyme levels were detected after the race in runners with LRTI when compared with those without infection. A decrease in salivary lysozyme, Groα and Groβ levels after the race were observed in those runners who did not develop a LRTI when compared to basal levels. Salivary Groα levels correlated with basophil blood counts, and salivary lysozyme levels correlated with leukocyte blood counts. CONCLUSIONS: LRTI are common after a marathon race in non-elite healthy runners. Changes in salivary antimicrobial proteins and chemokines are related to the presence of LRTI and correlate with systemic defense cells, which suggest an important role of salivary immunity in the development of LRTI in non-elite marathon runners.
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spelling pubmed-62488992018-12-06 Salivary immunity and lower respiratory tract infections in non-elite marathon runners Cantó, Elisabet Roca, Emma Perea, Lidia Rodrigo-Troyano, Ana Suarez-Cuartin, Guillermo Giner, Jordi Feliu, Anna Soria, Jose Manuel Nescolarde, Lexa Vidal, Silvia Sibila, Oriol PLoS One Research Article RATIONALE: Respiratory infections are common after strenuous exercise, when salivary immunity may be altered. We aim to investigate changes in salivary immunity after a marathon and its relationship with lower respiratory tract infections (LRTI) in healthy non-elite marathon runners. METHODS: Forty seven healthy marathon runners (28 males and 19 females) who completed the 42.195 km of the 2016 Barcelona marathon were studied. Saliva and blood samples were collected the day before the marathon and two days after the end of the race. Salivary IgA, antimicrobial proteins (lactoferrin, lysozyme) and chemokines (Groα, Groβ, MCP-1) were determined using ELISA kits in saliva supernatant. Blood biochemistry and haemogram were analyzed in all participants. The presence of LRTI was considered in those runners who reported infectious lower respiratory tract symptoms during a minimum of 3 consecutive days in the 2 weeks after the race. RESULTS: Eight participants (17%) presented a LRTI during the 2 weeks of follow-up. Higher lysozyme levels were detected after the race in runners with LRTI when compared with those without infection. A decrease in salivary lysozyme, Groα and Groβ levels after the race were observed in those runners who did not develop a LRTI when compared to basal levels. Salivary Groα levels correlated with basophil blood counts, and salivary lysozyme levels correlated with leukocyte blood counts. CONCLUSIONS: LRTI are common after a marathon race in non-elite healthy runners. Changes in salivary antimicrobial proteins and chemokines are related to the presence of LRTI and correlate with systemic defense cells, which suggest an important role of salivary immunity in the development of LRTI in non-elite marathon runners. Public Library of Science 2018-11-21 /pmc/articles/PMC6248899/ /pubmed/30462646 http://dx.doi.org/10.1371/journal.pone.0206059 Text en © 2018 Cantó et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Cantó, Elisabet
Roca, Emma
Perea, Lidia
Rodrigo-Troyano, Ana
Suarez-Cuartin, Guillermo
Giner, Jordi
Feliu, Anna
Soria, Jose Manuel
Nescolarde, Lexa
Vidal, Silvia
Sibila, Oriol
Salivary immunity and lower respiratory tract infections in non-elite marathon runners
title Salivary immunity and lower respiratory tract infections in non-elite marathon runners
title_full Salivary immunity and lower respiratory tract infections in non-elite marathon runners
title_fullStr Salivary immunity and lower respiratory tract infections in non-elite marathon runners
title_full_unstemmed Salivary immunity and lower respiratory tract infections in non-elite marathon runners
title_short Salivary immunity and lower respiratory tract infections in non-elite marathon runners
title_sort salivary immunity and lower respiratory tract infections in non-elite marathon runners
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248899/
https://www.ncbi.nlm.nih.gov/pubmed/30462646
http://dx.doi.org/10.1371/journal.pone.0206059
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