Triterpenoids manipulate a broad range of virus-host fusion via wrapping the HR2 domain prevalent in viral envelopes

A trimer-of-hairpins motif has been identified in triggering virus-cell fusion within a variety of viral envelopes. Chemically manipulating such a motif represents current repertoire of viral fusion inhibitors. Here, we report that triterpenoids, a class of natural products, antagonize this trimer-o...

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Detalles Bibliográficos
Autores principales: Si, Longlong, Meng, Kun, Tian, Zhenyu, Sun, Jiaqi, Li, Huiqiang, Zhang, Ziwei, Soloveva, Veronica, Li, Haiwei, Fu, Ge, Xia, Qing, Xiao, Sulong, Zhang, Lihe, Zhou, Demin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248931/
https://www.ncbi.nlm.nih.gov/pubmed/30474060
http://dx.doi.org/10.1126/sciadv.aau8408

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