HIV-1 vaccine design through minimizing envelope metastability

Overcoming envelope metastability is crucial to trimer-based HIV-1 vaccine design. Here, we present a coherent vaccine strategy by minimizing metastability. For 10 strains across five clades, we demonstrate that the gp41 ectodomain (gp41(ECTO)) is the main source of envelope metastability by replaci...

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Detalles Bibliográficos
Autores principales: He, Linling, Kumar, Sonu, Allen, Joel D., Huang, Deli, Lin, Xiaohe, Mann, Colin J., Saye-Francisco, Karen L., Copps, Jeffrey, Sarkar, Anita, Blizard, Gabrielle S., Ozorowski, Gabriel, Sok, Devin, Crispin, Max, Ward, Andrew B., Nemazee, David, Burton, Dennis R., Wilson, Ian A., Zhu, Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248932/
https://www.ncbi.nlm.nih.gov/pubmed/30474059
http://dx.doi.org/10.1126/sciadv.aau6769

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