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Functional analyses of heteromeric human PIEZO1 Channels

PIEZO1 and PIEZO2 are mechanosensitive channels (MSCs) important for cellular function and mutations in them lead to human disorders. We examined how functional heteromers form between subunits of PIEZO1 using the mutants E2117K, E2117D, and E2117A. Homomers of E2117K do not conduct. E2117A homomers...

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Detalles Bibliográficos
Autores principales:	Gnanasambandam, Radhakrishnan, Bae, Chilman, Ziegler, Lynn, Sachs, Frederick, Gottlieb, Philip A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248943/ https://www.ncbi.nlm.nih.gov/pubmed/30462693 http://dx.doi.org/10.1371/journal.pone.0207309

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