Cargando…

Entrainment and maintenance of an internal metronome in supplementary motor area

To prepare timely motor actions, we constantly predict future events. Regularly repeating events are often perceived as a rhythm to which we can readily synchronize our movements, just as in dancing to music. However, the neuronal mechanisms underlying the capacity to encode and maintain rhythms are...

Descripción completa

Detalles Bibliográficos
Autores principales: Cadena-Valencia, Jaime, García-Garibay, Otto, Merchant, Hugo, Jazayeri, Mehrdad, de Lafuente, Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249004/
https://www.ncbi.nlm.nih.gov/pubmed/30346275
http://dx.doi.org/10.7554/eLife.38983
_version_ 1783372671015190528
author Cadena-Valencia, Jaime
García-Garibay, Otto
Merchant, Hugo
Jazayeri, Mehrdad
de Lafuente, Victor
author_facet Cadena-Valencia, Jaime
García-Garibay, Otto
Merchant, Hugo
Jazayeri, Mehrdad
de Lafuente, Victor
author_sort Cadena-Valencia, Jaime
collection PubMed
description To prepare timely motor actions, we constantly predict future events. Regularly repeating events are often perceived as a rhythm to which we can readily synchronize our movements, just as in dancing to music. However, the neuronal mechanisms underlying the capacity to encode and maintain rhythms are not understood. We trained nonhuman primates to maintain the rhythm of a visual metronome of diverse tempos and recorded neural activity in the supplementary motor area (SMA). SMA exhibited rhythmic bursts of gamma band (30–40 Hz) reflecting an internal tempo that matched the extinguished visual metronome. Moreover, gamma amplitude increased throughout the trial, providing an estimate of total elapsed time. Notably, the timing of gamma bursts and firing rate modulations allowed predicting whether monkeys were ahead or behind the correct tempo. Our results indicate that SMA uses dynamic motor plans to encode a metronome for rhythms and a stopwatch for total elapsed time.
format Online
Article
Text
id pubmed-6249004
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher eLife Sciences Publications, Ltd
record_format MEDLINE/PubMed
spelling pubmed-62490042018-11-23 Entrainment and maintenance of an internal metronome in supplementary motor area Cadena-Valencia, Jaime García-Garibay, Otto Merchant, Hugo Jazayeri, Mehrdad de Lafuente, Victor eLife Neuroscience To prepare timely motor actions, we constantly predict future events. Regularly repeating events are often perceived as a rhythm to which we can readily synchronize our movements, just as in dancing to music. However, the neuronal mechanisms underlying the capacity to encode and maintain rhythms are not understood. We trained nonhuman primates to maintain the rhythm of a visual metronome of diverse tempos and recorded neural activity in the supplementary motor area (SMA). SMA exhibited rhythmic bursts of gamma band (30–40 Hz) reflecting an internal tempo that matched the extinguished visual metronome. Moreover, gamma amplitude increased throughout the trial, providing an estimate of total elapsed time. Notably, the timing of gamma bursts and firing rate modulations allowed predicting whether monkeys were ahead or behind the correct tempo. Our results indicate that SMA uses dynamic motor plans to encode a metronome for rhythms and a stopwatch for total elapsed time. eLife Sciences Publications, Ltd 2018-10-22 /pmc/articles/PMC6249004/ /pubmed/30346275 http://dx.doi.org/10.7554/eLife.38983 Text en © 2018, Cadena-Valencia et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Cadena-Valencia, Jaime
García-Garibay, Otto
Merchant, Hugo
Jazayeri, Mehrdad
de Lafuente, Victor
Entrainment and maintenance of an internal metronome in supplementary motor area
title Entrainment and maintenance of an internal metronome in supplementary motor area
title_full Entrainment and maintenance of an internal metronome in supplementary motor area
title_fullStr Entrainment and maintenance of an internal metronome in supplementary motor area
title_full_unstemmed Entrainment and maintenance of an internal metronome in supplementary motor area
title_short Entrainment and maintenance of an internal metronome in supplementary motor area
title_sort entrainment and maintenance of an internal metronome in supplementary motor area
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249004/
https://www.ncbi.nlm.nih.gov/pubmed/30346275
http://dx.doi.org/10.7554/eLife.38983
work_keys_str_mv AT cadenavalenciajaime entrainmentandmaintenanceofaninternalmetronomeinsupplementarymotorarea
AT garciagaribayotto entrainmentandmaintenanceofaninternalmetronomeinsupplementarymotorarea
AT merchanthugo entrainmentandmaintenanceofaninternalmetronomeinsupplementarymotorarea
AT jazayerimehrdad entrainmentandmaintenanceofaninternalmetronomeinsupplementarymotorarea
AT delafuentevictor entrainmentandmaintenanceofaninternalmetronomeinsupplementarymotorarea