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Entrainment and maintenance of an internal metronome in supplementary motor area
To prepare timely motor actions, we constantly predict future events. Regularly repeating events are often perceived as a rhythm to which we can readily synchronize our movements, just as in dancing to music. However, the neuronal mechanisms underlying the capacity to encode and maintain rhythms are...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249004/ https://www.ncbi.nlm.nih.gov/pubmed/30346275 http://dx.doi.org/10.7554/eLife.38983 |
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author | Cadena-Valencia, Jaime García-Garibay, Otto Merchant, Hugo Jazayeri, Mehrdad de Lafuente, Victor |
author_facet | Cadena-Valencia, Jaime García-Garibay, Otto Merchant, Hugo Jazayeri, Mehrdad de Lafuente, Victor |
author_sort | Cadena-Valencia, Jaime |
collection | PubMed |
description | To prepare timely motor actions, we constantly predict future events. Regularly repeating events are often perceived as a rhythm to which we can readily synchronize our movements, just as in dancing to music. However, the neuronal mechanisms underlying the capacity to encode and maintain rhythms are not understood. We trained nonhuman primates to maintain the rhythm of a visual metronome of diverse tempos and recorded neural activity in the supplementary motor area (SMA). SMA exhibited rhythmic bursts of gamma band (30–40 Hz) reflecting an internal tempo that matched the extinguished visual metronome. Moreover, gamma amplitude increased throughout the trial, providing an estimate of total elapsed time. Notably, the timing of gamma bursts and firing rate modulations allowed predicting whether monkeys were ahead or behind the correct tempo. Our results indicate that SMA uses dynamic motor plans to encode a metronome for rhythms and a stopwatch for total elapsed time. |
format | Online Article Text |
id | pubmed-6249004 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-62490042018-11-23 Entrainment and maintenance of an internal metronome in supplementary motor area Cadena-Valencia, Jaime García-Garibay, Otto Merchant, Hugo Jazayeri, Mehrdad de Lafuente, Victor eLife Neuroscience To prepare timely motor actions, we constantly predict future events. Regularly repeating events are often perceived as a rhythm to which we can readily synchronize our movements, just as in dancing to music. However, the neuronal mechanisms underlying the capacity to encode and maintain rhythms are not understood. We trained nonhuman primates to maintain the rhythm of a visual metronome of diverse tempos and recorded neural activity in the supplementary motor area (SMA). SMA exhibited rhythmic bursts of gamma band (30–40 Hz) reflecting an internal tempo that matched the extinguished visual metronome. Moreover, gamma amplitude increased throughout the trial, providing an estimate of total elapsed time. Notably, the timing of gamma bursts and firing rate modulations allowed predicting whether monkeys were ahead or behind the correct tempo. Our results indicate that SMA uses dynamic motor plans to encode a metronome for rhythms and a stopwatch for total elapsed time. eLife Sciences Publications, Ltd 2018-10-22 /pmc/articles/PMC6249004/ /pubmed/30346275 http://dx.doi.org/10.7554/eLife.38983 Text en © 2018, Cadena-Valencia et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Cadena-Valencia, Jaime García-Garibay, Otto Merchant, Hugo Jazayeri, Mehrdad de Lafuente, Victor Entrainment and maintenance of an internal metronome in supplementary motor area |
title | Entrainment and maintenance of an internal metronome in supplementary motor area |
title_full | Entrainment and maintenance of an internal metronome in supplementary motor area |
title_fullStr | Entrainment and maintenance of an internal metronome in supplementary motor area |
title_full_unstemmed | Entrainment and maintenance of an internal metronome in supplementary motor area |
title_short | Entrainment and maintenance of an internal metronome in supplementary motor area |
title_sort | entrainment and maintenance of an internal metronome in supplementary motor area |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249004/ https://www.ncbi.nlm.nih.gov/pubmed/30346275 http://dx.doi.org/10.7554/eLife.38983 |
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