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Biological activity of Pt(IV) prodrugs triggered by riboflavin-mediated bioorthogonal photocatalysis

We have recently demonstrated that riboflavin (Rf) functions as unconventional bioorthogonal photocatalyst for the activation of Pt(IV) prodrugs. In this study, we show how the combination of light and Rf with two Pt(IV) prodrugs is a feasible strategy for light-mediated pancreatic cancer cell death...

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Detalles Bibliográficos
Autores principales:	Alonso-de Castro, Silvia, Terenzi, Alessio, Hager, Sonja, Englinger, Bernhard, Faraone, Adriana, Martínez, Javier Calvo, Galanski, Mathea Sophia, Keppler, Bernhard K., Berger, Walter, Salassa, Luca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249213/ https://www.ncbi.nlm.nih.gov/pubmed/30464209 http://dx.doi.org/10.1038/s41598-018-35655-2

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