Big bottlenecks in cardiovascular tissue engineering

Although tissue engineering using human-induced pluripotent stem cells is a promising approach for treatment of cardiovascular diseases, some limiting factors include the survival, electrical integration, maturity, scalability, and immune response of three-dimensional (3D) engineered tissues. Here w...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Ngan F., Serpooshan, Vahid, Morris, Viola B., Sayed, Nazish, Pardon, Gaspard, Abilez, Oscar J., Nakayama, Karina H., Pruitt, Beth L., Wu, Sean M., Yoon, Young-sup, Zhang, Jianyi, Wu, Joseph C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249300/
https://www.ncbi.nlm.nih.gov/pubmed/30480100
http://dx.doi.org/10.1038/s42003-018-0202-8
_version_ 1783372717050822656
author Huang, Ngan F.
Serpooshan, Vahid
Morris, Viola B.
Sayed, Nazish
Pardon, Gaspard
Abilez, Oscar J.
Nakayama, Karina H.
Pruitt, Beth L.
Wu, Sean M.
Yoon, Young-sup
Zhang, Jianyi
Wu, Joseph C.
author_facet Huang, Ngan F.
Serpooshan, Vahid
Morris, Viola B.
Sayed, Nazish
Pardon, Gaspard
Abilez, Oscar J.
Nakayama, Karina H.
Pruitt, Beth L.
Wu, Sean M.
Yoon, Young-sup
Zhang, Jianyi
Wu, Joseph C.
author_sort Huang, Ngan F.
collection PubMed
description Although tissue engineering using human-induced pluripotent stem cells is a promising approach for treatment of cardiovascular diseases, some limiting factors include the survival, electrical integration, maturity, scalability, and immune response of three-dimensional (3D) engineered tissues. Here we discuss these important roadblocks facing the tissue engineering field and suggest potential approaches to overcome these challenges.
format Online
Article
Text
id pubmed-6249300
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-62493002018-11-26 Big bottlenecks in cardiovascular tissue engineering Huang, Ngan F. Serpooshan, Vahid Morris, Viola B. Sayed, Nazish Pardon, Gaspard Abilez, Oscar J. Nakayama, Karina H. Pruitt, Beth L. Wu, Sean M. Yoon, Young-sup Zhang, Jianyi Wu, Joseph C. Commun Biol Comment Although tissue engineering using human-induced pluripotent stem cells is a promising approach for treatment of cardiovascular diseases, some limiting factors include the survival, electrical integration, maturity, scalability, and immune response of three-dimensional (3D) engineered tissues. Here we discuss these important roadblocks facing the tissue engineering field and suggest potential approaches to overcome these challenges. Nature Publishing Group UK 2018-11-21 /pmc/articles/PMC6249300/ /pubmed/30480100 http://dx.doi.org/10.1038/s42003-018-0202-8 Text en © This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Comment
Huang, Ngan F.
Serpooshan, Vahid
Morris, Viola B.
Sayed, Nazish
Pardon, Gaspard
Abilez, Oscar J.
Nakayama, Karina H.
Pruitt, Beth L.
Wu, Sean M.
Yoon, Young-sup
Zhang, Jianyi
Wu, Joseph C.
Big bottlenecks in cardiovascular tissue engineering
title Big bottlenecks in cardiovascular tissue engineering
title_full Big bottlenecks in cardiovascular tissue engineering
title_fullStr Big bottlenecks in cardiovascular tissue engineering
title_full_unstemmed Big bottlenecks in cardiovascular tissue engineering
title_short Big bottlenecks in cardiovascular tissue engineering
title_sort big bottlenecks in cardiovascular tissue engineering
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249300/
https://www.ncbi.nlm.nih.gov/pubmed/30480100
http://dx.doi.org/10.1038/s42003-018-0202-8
work_keys_str_mv AT huangnganf bigbottlenecksincardiovasculartissueengineering
AT serpooshanvahid bigbottlenecksincardiovasculartissueengineering
AT morrisviolab bigbottlenecksincardiovasculartissueengineering
AT sayednazish bigbottlenecksincardiovasculartissueengineering
AT pardongaspard bigbottlenecksincardiovasculartissueengineering
AT abilezoscarj bigbottlenecksincardiovasculartissueengineering
AT nakayamakarinah bigbottlenecksincardiovasculartissueengineering
AT pruittbethl bigbottlenecksincardiovasculartissueengineering
AT wuseanm bigbottlenecksincardiovasculartissueengineering
AT yoonyoungsup bigbottlenecksincardiovasculartissueengineering
AT zhangjianyi bigbottlenecksincardiovasculartissueengineering
AT wujosephc bigbottlenecksincardiovasculartissueengineering

Ejemplares similares