CD180 Ligation Inhibits TLR7- and TLR9-Mediated Activation of Macrophages and Dendritic Cells Through the Lyn-SHP-1/2 Axis in Murine Lupus

Activation of TLR7 and TLR9 by endogenous RNA- or DNA-containing ligands, respectively, can lead to hyper-activation of immune cells, including macrophages and DCs, subsequently contributes to the pathogenesis of SLE. CD180, a TLR-like protein, is specifically involved in the development and activat...

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Detalles Bibliográficos
Autores principales: Yang, Yonghong, Wang, Cuiling, Cheng, Panpan, Zhang, Xiaobei, Li, Xuehui, Hu, Yuan, Xu, Feihong, Hong, Feng, Dong, Guanjun, Xiong, Huabao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249336/
https://www.ncbi.nlm.nih.gov/pubmed/30498494
http://dx.doi.org/10.3389/fimmu.2018.02643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249336/
https://www.ncbi.nlm.nih.gov/pubmed/30498494
http://dx.doi.org/10.3389/fimmu.2018.02643

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