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Interleukin-33 in Systemic Sclerosis: Expression and Pathogenesis

Interleukin-33 (IL-33), a member of the IL-1 superfamily, functions as a traditional cytokine and nuclear factor. It is proposed to have an “alarmin” role. IL-33 mediates biological effects by interacting with the ST2 receptor and IL-1 receptor accessory protein, particularly in innate immune cells...

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Detalles Bibliográficos
Autores principales: Li, Liya, Zhu, Honglin, Zuo, Xiaoxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249369/
https://www.ncbi.nlm.nih.gov/pubmed/30498500
http://dx.doi.org/10.3389/fimmu.2018.02663
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author Li, Liya
Zhu, Honglin
Zuo, Xiaoxia
author_facet Li, Liya
Zhu, Honglin
Zuo, Xiaoxia
author_sort Li, Liya
collection PubMed
description Interleukin-33 (IL-33), a member of the IL-1 superfamily, functions as a traditional cytokine and nuclear factor. It is proposed to have an “alarmin” role. IL-33 mediates biological effects by interacting with the ST2 receptor and IL-1 receptor accessory protein, particularly in innate immune cells and T helper 2 cells. Recent articles have described IL-33 as an emerging pro-fibrotic cytokine in the immune system as well as a novel potential target for systemic sclerosis. Here, we review the available information and focus on the pleiotropic expression and pathogenesis of IL-33 in systemic sclerosis, as well as the feasibility of using IL-33 in clinical applications.
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spelling pubmed-62493692018-11-29 Interleukin-33 in Systemic Sclerosis: Expression and Pathogenesis Li, Liya Zhu, Honglin Zuo, Xiaoxia Front Immunol Immunology Interleukin-33 (IL-33), a member of the IL-1 superfamily, functions as a traditional cytokine and nuclear factor. It is proposed to have an “alarmin” role. IL-33 mediates biological effects by interacting with the ST2 receptor and IL-1 receptor accessory protein, particularly in innate immune cells and T helper 2 cells. Recent articles have described IL-33 as an emerging pro-fibrotic cytokine in the immune system as well as a novel potential target for systemic sclerosis. Here, we review the available information and focus on the pleiotropic expression and pathogenesis of IL-33 in systemic sclerosis, as well as the feasibility of using IL-33 in clinical applications. Frontiers Media S.A. 2018-11-15 /pmc/articles/PMC6249369/ /pubmed/30498500 http://dx.doi.org/10.3389/fimmu.2018.02663 Text en Copyright © 2018 Li, Zhu and Zuo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Li, Liya
Zhu, Honglin
Zuo, Xiaoxia
Interleukin-33 in Systemic Sclerosis: Expression and Pathogenesis
title Interleukin-33 in Systemic Sclerosis: Expression and Pathogenesis
title_full Interleukin-33 in Systemic Sclerosis: Expression and Pathogenesis
title_fullStr Interleukin-33 in Systemic Sclerosis: Expression and Pathogenesis
title_full_unstemmed Interleukin-33 in Systemic Sclerosis: Expression and Pathogenesis
title_short Interleukin-33 in Systemic Sclerosis: Expression and Pathogenesis
title_sort interleukin-33 in systemic sclerosis: expression and pathogenesis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249369/
https://www.ncbi.nlm.nih.gov/pubmed/30498500
http://dx.doi.org/10.3389/fimmu.2018.02663
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