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Interleukin-33 in Systemic Sclerosis: Expression and Pathogenesis
Interleukin-33 (IL-33), a member of the IL-1 superfamily, functions as a traditional cytokine and nuclear factor. It is proposed to have an “alarmin” role. IL-33 mediates biological effects by interacting with the ST2 receptor and IL-1 receptor accessory protein, particularly in innate immune cells...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249369/ https://www.ncbi.nlm.nih.gov/pubmed/30498500 http://dx.doi.org/10.3389/fimmu.2018.02663 |
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author | Li, Liya Zhu, Honglin Zuo, Xiaoxia |
author_facet | Li, Liya Zhu, Honglin Zuo, Xiaoxia |
author_sort | Li, Liya |
collection | PubMed |
description | Interleukin-33 (IL-33), a member of the IL-1 superfamily, functions as a traditional cytokine and nuclear factor. It is proposed to have an “alarmin” role. IL-33 mediates biological effects by interacting with the ST2 receptor and IL-1 receptor accessory protein, particularly in innate immune cells and T helper 2 cells. Recent articles have described IL-33 as an emerging pro-fibrotic cytokine in the immune system as well as a novel potential target for systemic sclerosis. Here, we review the available information and focus on the pleiotropic expression and pathogenesis of IL-33 in systemic sclerosis, as well as the feasibility of using IL-33 in clinical applications. |
format | Online Article Text |
id | pubmed-6249369 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-62493692018-11-29 Interleukin-33 in Systemic Sclerosis: Expression and Pathogenesis Li, Liya Zhu, Honglin Zuo, Xiaoxia Front Immunol Immunology Interleukin-33 (IL-33), a member of the IL-1 superfamily, functions as a traditional cytokine and nuclear factor. It is proposed to have an “alarmin” role. IL-33 mediates biological effects by interacting with the ST2 receptor and IL-1 receptor accessory protein, particularly in innate immune cells and T helper 2 cells. Recent articles have described IL-33 as an emerging pro-fibrotic cytokine in the immune system as well as a novel potential target for systemic sclerosis. Here, we review the available information and focus on the pleiotropic expression and pathogenesis of IL-33 in systemic sclerosis, as well as the feasibility of using IL-33 in clinical applications. Frontiers Media S.A. 2018-11-15 /pmc/articles/PMC6249369/ /pubmed/30498500 http://dx.doi.org/10.3389/fimmu.2018.02663 Text en Copyright © 2018 Li, Zhu and Zuo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Li, Liya Zhu, Honglin Zuo, Xiaoxia Interleukin-33 in Systemic Sclerosis: Expression and Pathogenesis |
title | Interleukin-33 in Systemic Sclerosis: Expression and Pathogenesis |
title_full | Interleukin-33 in Systemic Sclerosis: Expression and Pathogenesis |
title_fullStr | Interleukin-33 in Systemic Sclerosis: Expression and Pathogenesis |
title_full_unstemmed | Interleukin-33 in Systemic Sclerosis: Expression and Pathogenesis |
title_short | Interleukin-33 in Systemic Sclerosis: Expression and Pathogenesis |
title_sort | interleukin-33 in systemic sclerosis: expression and pathogenesis |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249369/ https://www.ncbi.nlm.nih.gov/pubmed/30498500 http://dx.doi.org/10.3389/fimmu.2018.02663 |
work_keys_str_mv | AT liliya interleukin33insystemicsclerosisexpressionandpathogenesis AT zhuhonglin interleukin33insystemicsclerosisexpressionandpathogenesis AT zuoxiaoxia interleukin33insystemicsclerosisexpressionandpathogenesis |