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The Obesity and the Risk of Breast Cancer among Pre and Postmenopausal Women

BACKGROUND: Breast cancer is the most common cancer among women worldwide and the obesity is one of the factors related to the risk of breast cancer mainly in postmenopausal women. This study investigated the association between obesity in pre- and postmenopausal women with the development of breast...

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Autores principales: Gravena, Angela Andréia França, Lopes, Tiara Cristina Romeiro, Demitto, Marcela de Oliveira, Borghesan, Deise Helena Pelloso, Agnolo, Cátia Millene Dell’, Brischiliari, Sheila Cristina Rocha, Carvalho, Maria Dalva de Barros, Pelloso, Sandra Marisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249449/
https://www.ncbi.nlm.nih.gov/pubmed/30255696
http://dx.doi.org/10.22034/APJCP.2018.19.9.2429
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author Gravena, Angela Andréia França
Lopes, Tiara Cristina Romeiro
Demitto, Marcela de Oliveira
Borghesan, Deise Helena Pelloso
Agnolo, Cátia Millene Dell’
Brischiliari, Sheila Cristina Rocha
Carvalho, Maria Dalva de Barros
Pelloso, Sandra Marisa
author_facet Gravena, Angela Andréia França
Lopes, Tiara Cristina Romeiro
Demitto, Marcela de Oliveira
Borghesan, Deise Helena Pelloso
Agnolo, Cátia Millene Dell’
Brischiliari, Sheila Cristina Rocha
Carvalho, Maria Dalva de Barros
Pelloso, Sandra Marisa
author_sort Gravena, Angela Andréia França
collection PubMed
description BACKGROUND: Breast cancer is the most common cancer among women worldwide and the obesity is one of the factors related to the risk of breast cancer mainly in postmenopausal women. This study investigated the association between obesity in pre- and postmenopausal women with the development of breast cancer and the expression of estrogen, progesterone, HeR-2 and triple-negative (TN) receptors. METHODS: A case-control study was conducted on 100 patients with recently diagnosed breast cancer and 400 age-matched controls. The women were divided into pre- and post-menopausal groups. RESULTS: The multivariate analysis showed that postmenopausal women with a BMI ≥ 30 kg/m(2) at pre-diagnosis and at the most recent measurement were 1.50 (95% CI 1.06-2.13) and 1.56 (95% CI 1.11-2.21) times more likely to develop breast cancer, respectively. These women had a prevalence of obesity of 27.7% when considering pre-diagnosis BMI and 29.4% when analyzing the indicator of recent BMI. When only the cases regarding the presence of obesity with clinicopathological variables were analyzed, a total of 95.2% of the postmenopausal women with pre-diagnostic obesity according to BMI presented the positive estrogen receptor (ER) subtype. CONCLUSIONS: In Brazilian women, there is an association between obesity and the risk of breast cancer postmenopause; moreover, there is an association between the occurrence of the positive ER subtype in postmenopausal women and pre-diagnostic obesity according to BMI.
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spelling pubmed-62494492018-12-07 The Obesity and the Risk of Breast Cancer among Pre and Postmenopausal Women Gravena, Angela Andréia França Lopes, Tiara Cristina Romeiro Demitto, Marcela de Oliveira Borghesan, Deise Helena Pelloso Agnolo, Cátia Millene Dell’ Brischiliari, Sheila Cristina Rocha Carvalho, Maria Dalva de Barros Pelloso, Sandra Marisa Asian Pac J Cancer Prev Research Article BACKGROUND: Breast cancer is the most common cancer among women worldwide and the obesity is one of the factors related to the risk of breast cancer mainly in postmenopausal women. This study investigated the association between obesity in pre- and postmenopausal women with the development of breast cancer and the expression of estrogen, progesterone, HeR-2 and triple-negative (TN) receptors. METHODS: A case-control study was conducted on 100 patients with recently diagnosed breast cancer and 400 age-matched controls. The women were divided into pre- and post-menopausal groups. RESULTS: The multivariate analysis showed that postmenopausal women with a BMI ≥ 30 kg/m(2) at pre-diagnosis and at the most recent measurement were 1.50 (95% CI 1.06-2.13) and 1.56 (95% CI 1.11-2.21) times more likely to develop breast cancer, respectively. These women had a prevalence of obesity of 27.7% when considering pre-diagnosis BMI and 29.4% when analyzing the indicator of recent BMI. When only the cases regarding the presence of obesity with clinicopathological variables were analyzed, a total of 95.2% of the postmenopausal women with pre-diagnostic obesity according to BMI presented the positive estrogen receptor (ER) subtype. CONCLUSIONS: In Brazilian women, there is an association between obesity and the risk of breast cancer postmenopause; moreover, there is an association between the occurrence of the positive ER subtype in postmenopausal women and pre-diagnostic obesity according to BMI. West Asia Organization for Cancer Prevention 2018 /pmc/articles/PMC6249449/ /pubmed/30255696 http://dx.doi.org/10.22034/APJCP.2018.19.9.2429 Text en Copyright: © Asian Pacific Journal of Cancer Prevention http://creativecommons.org/licenses/BY-SA/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
spellingShingle Research Article
Gravena, Angela Andréia França
Lopes, Tiara Cristina Romeiro
Demitto, Marcela de Oliveira
Borghesan, Deise Helena Pelloso
Agnolo, Cátia Millene Dell’
Brischiliari, Sheila Cristina Rocha
Carvalho, Maria Dalva de Barros
Pelloso, Sandra Marisa
The Obesity and the Risk of Breast Cancer among Pre and Postmenopausal Women
title The Obesity and the Risk of Breast Cancer among Pre and Postmenopausal Women
title_full The Obesity and the Risk of Breast Cancer among Pre and Postmenopausal Women
title_fullStr The Obesity and the Risk of Breast Cancer among Pre and Postmenopausal Women
title_full_unstemmed The Obesity and the Risk of Breast Cancer among Pre and Postmenopausal Women
title_short The Obesity and the Risk of Breast Cancer among Pre and Postmenopausal Women
title_sort obesity and the risk of breast cancer among pre and postmenopausal women
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249449/
https://www.ncbi.nlm.nih.gov/pubmed/30255696
http://dx.doi.org/10.22034/APJCP.2018.19.9.2429
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