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The Obesity and the Risk of Breast Cancer among Pre and Postmenopausal Women
BACKGROUND: Breast cancer is the most common cancer among women worldwide and the obesity is one of the factors related to the risk of breast cancer mainly in postmenopausal women. This study investigated the association between obesity in pre- and postmenopausal women with the development of breast...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
West Asia Organization for Cancer Prevention
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249449/ https://www.ncbi.nlm.nih.gov/pubmed/30255696 http://dx.doi.org/10.22034/APJCP.2018.19.9.2429 |
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author | Gravena, Angela Andréia França Lopes, Tiara Cristina Romeiro Demitto, Marcela de Oliveira Borghesan, Deise Helena Pelloso Agnolo, Cátia Millene Dell’ Brischiliari, Sheila Cristina Rocha Carvalho, Maria Dalva de Barros Pelloso, Sandra Marisa |
author_facet | Gravena, Angela Andréia França Lopes, Tiara Cristina Romeiro Demitto, Marcela de Oliveira Borghesan, Deise Helena Pelloso Agnolo, Cátia Millene Dell’ Brischiliari, Sheila Cristina Rocha Carvalho, Maria Dalva de Barros Pelloso, Sandra Marisa |
author_sort | Gravena, Angela Andréia França |
collection | PubMed |
description | BACKGROUND: Breast cancer is the most common cancer among women worldwide and the obesity is one of the factors related to the risk of breast cancer mainly in postmenopausal women. This study investigated the association between obesity in pre- and postmenopausal women with the development of breast cancer and the expression of estrogen, progesterone, HeR-2 and triple-negative (TN) receptors. METHODS: A case-control study was conducted on 100 patients with recently diagnosed breast cancer and 400 age-matched controls. The women were divided into pre- and post-menopausal groups. RESULTS: The multivariate analysis showed that postmenopausal women with a BMI ≥ 30 kg/m(2) at pre-diagnosis and at the most recent measurement were 1.50 (95% CI 1.06-2.13) and 1.56 (95% CI 1.11-2.21) times more likely to develop breast cancer, respectively. These women had a prevalence of obesity of 27.7% when considering pre-diagnosis BMI and 29.4% when analyzing the indicator of recent BMI. When only the cases regarding the presence of obesity with clinicopathological variables were analyzed, a total of 95.2% of the postmenopausal women with pre-diagnostic obesity according to BMI presented the positive estrogen receptor (ER) subtype. CONCLUSIONS: In Brazilian women, there is an association between obesity and the risk of breast cancer postmenopause; moreover, there is an association between the occurrence of the positive ER subtype in postmenopausal women and pre-diagnostic obesity according to BMI. |
format | Online Article Text |
id | pubmed-6249449 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | West Asia Organization for Cancer Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-62494492018-12-07 The Obesity and the Risk of Breast Cancer among Pre and Postmenopausal Women Gravena, Angela Andréia França Lopes, Tiara Cristina Romeiro Demitto, Marcela de Oliveira Borghesan, Deise Helena Pelloso Agnolo, Cátia Millene Dell’ Brischiliari, Sheila Cristina Rocha Carvalho, Maria Dalva de Barros Pelloso, Sandra Marisa Asian Pac J Cancer Prev Research Article BACKGROUND: Breast cancer is the most common cancer among women worldwide and the obesity is one of the factors related to the risk of breast cancer mainly in postmenopausal women. This study investigated the association between obesity in pre- and postmenopausal women with the development of breast cancer and the expression of estrogen, progesterone, HeR-2 and triple-negative (TN) receptors. METHODS: A case-control study was conducted on 100 patients with recently diagnosed breast cancer and 400 age-matched controls. The women were divided into pre- and post-menopausal groups. RESULTS: The multivariate analysis showed that postmenopausal women with a BMI ≥ 30 kg/m(2) at pre-diagnosis and at the most recent measurement were 1.50 (95% CI 1.06-2.13) and 1.56 (95% CI 1.11-2.21) times more likely to develop breast cancer, respectively. These women had a prevalence of obesity of 27.7% when considering pre-diagnosis BMI and 29.4% when analyzing the indicator of recent BMI. When only the cases regarding the presence of obesity with clinicopathological variables were analyzed, a total of 95.2% of the postmenopausal women with pre-diagnostic obesity according to BMI presented the positive estrogen receptor (ER) subtype. CONCLUSIONS: In Brazilian women, there is an association between obesity and the risk of breast cancer postmenopause; moreover, there is an association between the occurrence of the positive ER subtype in postmenopausal women and pre-diagnostic obesity according to BMI. West Asia Organization for Cancer Prevention 2018 /pmc/articles/PMC6249449/ /pubmed/30255696 http://dx.doi.org/10.22034/APJCP.2018.19.9.2429 Text en Copyright: © Asian Pacific Journal of Cancer Prevention http://creativecommons.org/licenses/BY-SA/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License |
spellingShingle | Research Article Gravena, Angela Andréia França Lopes, Tiara Cristina Romeiro Demitto, Marcela de Oliveira Borghesan, Deise Helena Pelloso Agnolo, Cátia Millene Dell’ Brischiliari, Sheila Cristina Rocha Carvalho, Maria Dalva de Barros Pelloso, Sandra Marisa The Obesity and the Risk of Breast Cancer among Pre and Postmenopausal Women |
title | The Obesity and the Risk of Breast Cancer among Pre and Postmenopausal Women |
title_full | The Obesity and the Risk of Breast Cancer among Pre and Postmenopausal Women |
title_fullStr | The Obesity and the Risk of Breast Cancer among Pre and Postmenopausal Women |
title_full_unstemmed | The Obesity and the Risk of Breast Cancer among Pre and Postmenopausal Women |
title_short | The Obesity and the Risk of Breast Cancer among Pre and Postmenopausal Women |
title_sort | obesity and the risk of breast cancer among pre and postmenopausal women |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249449/ https://www.ncbi.nlm.nih.gov/pubmed/30255696 http://dx.doi.org/10.22034/APJCP.2018.19.9.2429 |
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