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Repurposing existing drugs: identification of irreversible IMPDH inhibitors by high-throughput screening

Inosine 5′-monophosphate dehydrogenase (IMPDH) is an essential enzyme for the production of guanine nucleotides. Disruption of IMPDH activity has been explored as a therapeutic strategy for numerous purposes, such as for anticancer, immunosuppression, antiviral, and antimicrobial therapy. In the pre...

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Detalles Bibliográficos
Autores principales:	Sarwono, Albertus Eka Yudistira, Mitsuhashi, Shinya, Kabir, Mohammad Hazzaz Bin, Shigetomi, Kengo, Okada, Tadashi, Ohsaka, Fumina, Otsuguro, Satoko, Maenaka, Katsumi, Igarashi, Makoto, Kato, Kentaro, Ubukata, Makoto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249553/ https://www.ncbi.nlm.nih.gov/pubmed/30451014 http://dx.doi.org/10.1080/14756366.2018.1540474

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