Development of Clinical-Stage Human Monoclonal Antibodies That Treat Advanced Ebola Virus Disease in Nonhuman Primates

BACKGROUND: For most classes of drugs, rapid development of therapeutics to treat emerging infections is challenged by the timelines needed to identify compounds with the desired efficacy, safety, and pharmacokinetic profiles. Fully human monoclonal antibodies (mAbs) provide an attractive method to...

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Autores principales: Pascal, Kristen E, Dudgeon, Drew, Trefry, John C, Anantpadma, Manu, Sakurai, Yasuteru, Murin, Charles D, Turner, Hannah L, Fairhurst, Jeanette, Torres, Marcela, Rafique, Ashique, Yan, Ying, Badithe, Ashok, Yu, Kevin, Potocky, Terra, Bixler, Sandra L, Chance, Taylor B, Pratt, William D, Rossi, Franco D, Shamblin, Joshua D, Wollen, Suzanne E, Zelko, Justine M, Carrion, Ricardo, Worwa, Gabriella, Staples, Hilary M, Burakov, Darya, Babb, Robert, Chen, Gang, Martin, Joel, Huang, Tammy T, Erlandson, Karl, Willis, Melissa S, Armstrong, Kimberly, Dreier, Thomas M, Ward, Andrew B, Davey, Robert A, Pitt, Margaret L M, Lipsich, Leah, Mason, Peter, Olson, William, Stahl, Neil, Kyratsous, Christos A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Supplement Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249601/
https://www.ncbi.nlm.nih.gov/pubmed/29860496
http://dx.doi.org/10.1093/infdis/jiy285

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