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Metformin sensitizes hypoxia-induced gefitinib treatment resistance of HNSCC via cell cycle regulation and EMT reversal

OBJECTIVES: The objectives of this study were to explore the mechanisms of metformin sensitization to hypoxia-induced gefitinib treatment in resistant head and neck squamous cell carcinoma (HNSCC) and evaluate the effects of this combined treatment strategy. METHODS: The effects of gefitinib treatme...

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Detalles Bibliográficos
Autores principales:	Yin, Xiteng, Wei, Zheng, Song, Chuanhui, Tang, Chuanchao, Xu, Wenguang, Wang, Yufeng, Xie, Junqi, Lin, Zitong, Han, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250113/ https://www.ncbi.nlm.nih.gov/pubmed/30510448 http://dx.doi.org/10.2147/CMAR.S177473

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