Renal Klotho is Reduced in Septic Patients and Pretreatment With Recombinant Klotho Attenuates Organ Injury in Lipopolysaccharide-Challenged Mice

OBJECTIVES: To determine the applicability of recombinant Klotho to prevent inflammation and organ injury in sepsis in man and mice. DESIGN: Prospective, clinical laboratory study using “warm” human postmortem sepsis-acute kidney injury biopsies. Laboratory study using a mouse model of endotoxemia....

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Detalles Bibliográficos
Autores principales: Jou-Valencia, Daniela, Molema, Grietje, Popa, Eliane, Aslan, Adnan, van Dijk, Fransien, Mencke, Rik, Hillebrands, Jan-Luuk, Heeringa, Peter, Hoenderop, Joost G., Zijlstra, Jan G., van Meurs, Matijs, Moser, Jill
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2018
Materias:
Online Laboratory Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250245/
https://www.ncbi.nlm.nih.gov/pubmed/30239382
http://dx.doi.org/10.1097/CCM.0000000000003427

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