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Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H: quinone oxidoreductase 1 (NQO1)

The human NAD(P)H:quinone oxidoreductase 1 (NQO1; EC 1.6.99.2) is an essential enzyme in the antioxidant defence system. Furthermore, NQO1 protects tumour suppressors like p53, p33(ING1b) and p73 from proteasomal degradation. The activity of NQO1 is also exploited in chemotherapy for the activation...

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Detalles Bibliográficos
Autores principales:	Lienhart, Wolf-Dieter, Strandback, Emilia, Gudipati, Venugopal, Koch, Karin, Binter, Alexandra, Uhl, Michael K., Rantasa, David M., Bourgeois, Benjamin, Madl, Tobias, Zangger, Klaus, Gruber, Karl, Macheroux, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250432/ https://www.ncbi.nlm.nih.gov/pubmed/28236663 http://dx.doi.org/10.1111/febs.14051

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