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Orbitomaxillofacial Mucormycosis Requiring Complex Multifactorial Management

Mucormycosis is a rare fungal infection caused by ubiquitous fungi in the order Mucorales. It is the most rapidly progressing fulminant fungal infection that mimics necrotizing soft-tissue infections. Overwhelming fungal sepsis develops quickly and mortality rates approach 70%. Culture negative necr...

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Detalles Bibliográficos
Autores principales: Steve, Anna K., Hurdle, Valerie A., Brown, Jevon Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250482/
https://www.ncbi.nlm.nih.gov/pubmed/30534490
http://dx.doi.org/10.1097/GOX.0000000000001927
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author Steve, Anna K.
Hurdle, Valerie A.
Brown, Jevon Y.
author_facet Steve, Anna K.
Hurdle, Valerie A.
Brown, Jevon Y.
author_sort Steve, Anna K.
collection PubMed
description Mucormycosis is a rare fungal infection caused by ubiquitous fungi in the order Mucorales. It is the most rapidly progressing fulminant fungal infection that mimics necrotizing soft-tissue infections. Overwhelming fungal sepsis develops quickly and mortality rates approach 70%. Culture negative necrotizing infections and cutaneous necrosis following a vascular pattern should raise suspicion for this rare entity. We describe avoiding mortality in a case of orbitomaxillofacial mucormycosis multifactorially treated with: radical serial debridement, topical amphotericin B irrigation and dressings, parenteral amphotericin B, and hyperbaric oxygen therapy. Tissue biopsy was central to confirming the diagnosis and directing multimodal management that ultimately prevented dissemination to the central nervous system and mortality.
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spelling pubmed-62504822018-12-10 Orbitomaxillofacial Mucormycosis Requiring Complex Multifactorial Management Steve, Anna K. Hurdle, Valerie A. Brown, Jevon Y. Plast Reconstr Surg Glob Open Case Report Mucormycosis is a rare fungal infection caused by ubiquitous fungi in the order Mucorales. It is the most rapidly progressing fulminant fungal infection that mimics necrotizing soft-tissue infections. Overwhelming fungal sepsis develops quickly and mortality rates approach 70%. Culture negative necrotizing infections and cutaneous necrosis following a vascular pattern should raise suspicion for this rare entity. We describe avoiding mortality in a case of orbitomaxillofacial mucormycosis multifactorially treated with: radical serial debridement, topical amphotericin B irrigation and dressings, parenteral amphotericin B, and hyperbaric oxygen therapy. Tissue biopsy was central to confirming the diagnosis and directing multimodal management that ultimately prevented dissemination to the central nervous system and mortality. Wolters Kluwer Health 2018-10-02 /pmc/articles/PMC6250482/ /pubmed/30534490 http://dx.doi.org/10.1097/GOX.0000000000001927 Text en Copyright © 2018 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Steve, Anna K.
Hurdle, Valerie A.
Brown, Jevon Y.
Orbitomaxillofacial Mucormycosis Requiring Complex Multifactorial Management
title Orbitomaxillofacial Mucormycosis Requiring Complex Multifactorial Management
title_full Orbitomaxillofacial Mucormycosis Requiring Complex Multifactorial Management
title_fullStr Orbitomaxillofacial Mucormycosis Requiring Complex Multifactorial Management
title_full_unstemmed Orbitomaxillofacial Mucormycosis Requiring Complex Multifactorial Management
title_short Orbitomaxillofacial Mucormycosis Requiring Complex Multifactorial Management
title_sort orbitomaxillofacial mucormycosis requiring complex multifactorial management
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250482/
https://www.ncbi.nlm.nih.gov/pubmed/30534490
http://dx.doi.org/10.1097/GOX.0000000000001927
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