Cargando…

Clinicopathologic characteristics in patients with upper third gastric cancer following radical surgical treatment: A retrospective cohort study

The incidences of upper third gastric cancer (UTGC) have been increasing. However, the prognostic factors for UTGC following radical surgical treatment remains largely unknown. This study was to investigate prognostic factors for overall survival (OS), lymph node metastasis and recurrence of UTGC. C...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Xiaoming, Zhou, Wei, Wang, Cheng, Miao, Wei, Liu, Ning, Wang, Shigui, Guan, Shihao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250511/
https://www.ncbi.nlm.nih.gov/pubmed/30407293
http://dx.doi.org/10.1097/MD.0000000000013017
_version_ 1783372928617807872
author Ma, Xiaoming
Zhou, Wei
Wang, Cheng
Miao, Wei
Liu, Ning
Wang, Shigui
Guan, Shihao
author_facet Ma, Xiaoming
Zhou, Wei
Wang, Cheng
Miao, Wei
Liu, Ning
Wang, Shigui
Guan, Shihao
author_sort Ma, Xiaoming
collection PubMed
description The incidences of upper third gastric cancer (UTGC) have been increasing. However, the prognostic factors for UTGC following radical surgical treatment remains largely unknown. This study was to investigate prognostic factors for overall survival (OS), lymph node metastasis and recurrence of UTGC. Clinicopathologic data of 126 UTGC patients who underwent radical surgical treatment were retrospectively analyzed. OS and univariate analysis were determined by Kaplan–Meier analysis and the significance of the difference between curves was calculated with the log-rank test. The Cox proportional hazards regression model was applied to perform multivariate analysis. Receiver operating characteristic (ROC) curve analysis was used to determine the prognostic accuracy. The 1-, 3-, and 5-year OS for patients with UTGC were 81%, 47.6%, and 38.6% respectively. Univariate analysis showed that tumor size (P = .019), tumor invasion depth (P < .001), and lymph node metastasis (P < .001) were the risk factors for 5-year OS. Multivariate analysis identified tumor invasion depth (P < .001) and lymph node metastasis (P < .001) as independent prognostic factors for the 5-year OS in patients with UTGC. In addition, ROC curve analysis showed that tumor invasion depth (P = .017) or lymph node metastasis (P = .001) alone showed significantly effective prognosis for the 5-year OS in patients with UTGC. For UTGC patients with lymph node metastasis, tumor size (P = .023), lym embolism (P = .003), tumor invasion depth (P = .002), and invasion of tunica serosa (P = .004) were the risk factors for the 5-year OS. Multivariate analysis identified tumor size (P = .048), lym embolism (P = .032), tumor invasion depth (P = .004), and invasion of tunica serosa (P = .031) as independent prognostic factors for the 5-year OS. For UTGC patients with distant metastasis or tumor recurrence, univariate and multivariate analyses demonstrated that tumor invasion depth and lymph node metastasis were independent prognostic factors for the 5-year OS. The results suggested that for UPGC patients undergoing the radical surgical treatment, tumor invasion depth and/or lymph node metastasis are the independent prognostic factors for the 5-year OS, lymph node metastasis, distant metastasis and tumor recurrence.
format Online
Article
Text
id pubmed-6250511
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-62505112018-12-10 Clinicopathologic characteristics in patients with upper third gastric cancer following radical surgical treatment: A retrospective cohort study Ma, Xiaoming Zhou, Wei Wang, Cheng Miao, Wei Liu, Ning Wang, Shigui Guan, Shihao Medicine (Baltimore) Research Article The incidences of upper third gastric cancer (UTGC) have been increasing. However, the prognostic factors for UTGC following radical surgical treatment remains largely unknown. This study was to investigate prognostic factors for overall survival (OS), lymph node metastasis and recurrence of UTGC. Clinicopathologic data of 126 UTGC patients who underwent radical surgical treatment were retrospectively analyzed. OS and univariate analysis were determined by Kaplan–Meier analysis and the significance of the difference between curves was calculated with the log-rank test. The Cox proportional hazards regression model was applied to perform multivariate analysis. Receiver operating characteristic (ROC) curve analysis was used to determine the prognostic accuracy. The 1-, 3-, and 5-year OS for patients with UTGC were 81%, 47.6%, and 38.6% respectively. Univariate analysis showed that tumor size (P = .019), tumor invasion depth (P < .001), and lymph node metastasis (P < .001) were the risk factors for 5-year OS. Multivariate analysis identified tumor invasion depth (P < .001) and lymph node metastasis (P < .001) as independent prognostic factors for the 5-year OS in patients with UTGC. In addition, ROC curve analysis showed that tumor invasion depth (P = .017) or lymph node metastasis (P = .001) alone showed significantly effective prognosis for the 5-year OS in patients with UTGC. For UTGC patients with lymph node metastasis, tumor size (P = .023), lym embolism (P = .003), tumor invasion depth (P = .002), and invasion of tunica serosa (P = .004) were the risk factors for the 5-year OS. Multivariate analysis identified tumor size (P = .048), lym embolism (P = .032), tumor invasion depth (P = .004), and invasion of tunica serosa (P = .031) as independent prognostic factors for the 5-year OS. For UTGC patients with distant metastasis or tumor recurrence, univariate and multivariate analyses demonstrated that tumor invasion depth and lymph node metastasis were independent prognostic factors for the 5-year OS. The results suggested that for UPGC patients undergoing the radical surgical treatment, tumor invasion depth and/or lymph node metastasis are the independent prognostic factors for the 5-year OS, lymph node metastasis, distant metastasis and tumor recurrence. Wolters Kluwer Health 2018-11-09 /pmc/articles/PMC6250511/ /pubmed/30407293 http://dx.doi.org/10.1097/MD.0000000000013017 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Research Article
Ma, Xiaoming
Zhou, Wei
Wang, Cheng
Miao, Wei
Liu, Ning
Wang, Shigui
Guan, Shihao
Clinicopathologic characteristics in patients with upper third gastric cancer following radical surgical treatment: A retrospective cohort study
title Clinicopathologic characteristics in patients with upper third gastric cancer following radical surgical treatment: A retrospective cohort study
title_full Clinicopathologic characteristics in patients with upper third gastric cancer following radical surgical treatment: A retrospective cohort study
title_fullStr Clinicopathologic characteristics in patients with upper third gastric cancer following radical surgical treatment: A retrospective cohort study
title_full_unstemmed Clinicopathologic characteristics in patients with upper third gastric cancer following radical surgical treatment: A retrospective cohort study
title_short Clinicopathologic characteristics in patients with upper third gastric cancer following radical surgical treatment: A retrospective cohort study
title_sort clinicopathologic characteristics in patients with upper third gastric cancer following radical surgical treatment: a retrospective cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250511/
https://www.ncbi.nlm.nih.gov/pubmed/30407293
http://dx.doi.org/10.1097/MD.0000000000013017
work_keys_str_mv AT maxiaoming clinicopathologiccharacteristicsinpatientswithupperthirdgastriccancerfollowingradicalsurgicaltreatmentaretrospectivecohortstudy
AT zhouwei clinicopathologiccharacteristicsinpatientswithupperthirdgastriccancerfollowingradicalsurgicaltreatmentaretrospectivecohortstudy
AT wangcheng clinicopathologiccharacteristicsinpatientswithupperthirdgastriccancerfollowingradicalsurgicaltreatmentaretrospectivecohortstudy
AT miaowei clinicopathologiccharacteristicsinpatientswithupperthirdgastriccancerfollowingradicalsurgicaltreatmentaretrospectivecohortstudy
AT liuning clinicopathologiccharacteristicsinpatientswithupperthirdgastriccancerfollowingradicalsurgicaltreatmentaretrospectivecohortstudy
AT wangshigui clinicopathologiccharacteristicsinpatientswithupperthirdgastriccancerfollowingradicalsurgicaltreatmentaretrospectivecohortstudy
AT guanshihao clinicopathologiccharacteristicsinpatientswithupperthirdgastriccancerfollowingradicalsurgicaltreatmentaretrospectivecohortstudy