Cargando…
Clinicopathologic characteristics in patients with upper third gastric cancer following radical surgical treatment: A retrospective cohort study
The incidences of upper third gastric cancer (UTGC) have been increasing. However, the prognostic factors for UTGC following radical surgical treatment remains largely unknown. This study was to investigate prognostic factors for overall survival (OS), lymph node metastasis and recurrence of UTGC. C...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250511/ https://www.ncbi.nlm.nih.gov/pubmed/30407293 http://dx.doi.org/10.1097/MD.0000000000013017 |
_version_ | 1783372928617807872 |
---|---|
author | Ma, Xiaoming Zhou, Wei Wang, Cheng Miao, Wei Liu, Ning Wang, Shigui Guan, Shihao |
author_facet | Ma, Xiaoming Zhou, Wei Wang, Cheng Miao, Wei Liu, Ning Wang, Shigui Guan, Shihao |
author_sort | Ma, Xiaoming |
collection | PubMed |
description | The incidences of upper third gastric cancer (UTGC) have been increasing. However, the prognostic factors for UTGC following radical surgical treatment remains largely unknown. This study was to investigate prognostic factors for overall survival (OS), lymph node metastasis and recurrence of UTGC. Clinicopathologic data of 126 UTGC patients who underwent radical surgical treatment were retrospectively analyzed. OS and univariate analysis were determined by Kaplan–Meier analysis and the significance of the difference between curves was calculated with the log-rank test. The Cox proportional hazards regression model was applied to perform multivariate analysis. Receiver operating characteristic (ROC) curve analysis was used to determine the prognostic accuracy. The 1-, 3-, and 5-year OS for patients with UTGC were 81%, 47.6%, and 38.6% respectively. Univariate analysis showed that tumor size (P = .019), tumor invasion depth (P < .001), and lymph node metastasis (P < .001) were the risk factors for 5-year OS. Multivariate analysis identified tumor invasion depth (P < .001) and lymph node metastasis (P < .001) as independent prognostic factors for the 5-year OS in patients with UTGC. In addition, ROC curve analysis showed that tumor invasion depth (P = .017) or lymph node metastasis (P = .001) alone showed significantly effective prognosis for the 5-year OS in patients with UTGC. For UTGC patients with lymph node metastasis, tumor size (P = .023), lym embolism (P = .003), tumor invasion depth (P = .002), and invasion of tunica serosa (P = .004) were the risk factors for the 5-year OS. Multivariate analysis identified tumor size (P = .048), lym embolism (P = .032), tumor invasion depth (P = .004), and invasion of tunica serosa (P = .031) as independent prognostic factors for the 5-year OS. For UTGC patients with distant metastasis or tumor recurrence, univariate and multivariate analyses demonstrated that tumor invasion depth and lymph node metastasis were independent prognostic factors for the 5-year OS. The results suggested that for UPGC patients undergoing the radical surgical treatment, tumor invasion depth and/or lymph node metastasis are the independent prognostic factors for the 5-year OS, lymph node metastasis, distant metastasis and tumor recurrence. |
format | Online Article Text |
id | pubmed-6250511 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-62505112018-12-10 Clinicopathologic characteristics in patients with upper third gastric cancer following radical surgical treatment: A retrospective cohort study Ma, Xiaoming Zhou, Wei Wang, Cheng Miao, Wei Liu, Ning Wang, Shigui Guan, Shihao Medicine (Baltimore) Research Article The incidences of upper third gastric cancer (UTGC) have been increasing. However, the prognostic factors for UTGC following radical surgical treatment remains largely unknown. This study was to investigate prognostic factors for overall survival (OS), lymph node metastasis and recurrence of UTGC. Clinicopathologic data of 126 UTGC patients who underwent radical surgical treatment were retrospectively analyzed. OS and univariate analysis were determined by Kaplan–Meier analysis and the significance of the difference between curves was calculated with the log-rank test. The Cox proportional hazards regression model was applied to perform multivariate analysis. Receiver operating characteristic (ROC) curve analysis was used to determine the prognostic accuracy. The 1-, 3-, and 5-year OS for patients with UTGC were 81%, 47.6%, and 38.6% respectively. Univariate analysis showed that tumor size (P = .019), tumor invasion depth (P < .001), and lymph node metastasis (P < .001) were the risk factors for 5-year OS. Multivariate analysis identified tumor invasion depth (P < .001) and lymph node metastasis (P < .001) as independent prognostic factors for the 5-year OS in patients with UTGC. In addition, ROC curve analysis showed that tumor invasion depth (P = .017) or lymph node metastasis (P = .001) alone showed significantly effective prognosis for the 5-year OS in patients with UTGC. For UTGC patients with lymph node metastasis, tumor size (P = .023), lym embolism (P = .003), tumor invasion depth (P = .002), and invasion of tunica serosa (P = .004) were the risk factors for the 5-year OS. Multivariate analysis identified tumor size (P = .048), lym embolism (P = .032), tumor invasion depth (P = .004), and invasion of tunica serosa (P = .031) as independent prognostic factors for the 5-year OS. For UTGC patients with distant metastasis or tumor recurrence, univariate and multivariate analyses demonstrated that tumor invasion depth and lymph node metastasis were independent prognostic factors for the 5-year OS. The results suggested that for UPGC patients undergoing the radical surgical treatment, tumor invasion depth and/or lymph node metastasis are the independent prognostic factors for the 5-year OS, lymph node metastasis, distant metastasis and tumor recurrence. Wolters Kluwer Health 2018-11-09 /pmc/articles/PMC6250511/ /pubmed/30407293 http://dx.doi.org/10.1097/MD.0000000000013017 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | Research Article Ma, Xiaoming Zhou, Wei Wang, Cheng Miao, Wei Liu, Ning Wang, Shigui Guan, Shihao Clinicopathologic characteristics in patients with upper third gastric cancer following radical surgical treatment: A retrospective cohort study |
title | Clinicopathologic characteristics in patients with upper third gastric cancer following radical surgical treatment: A retrospective cohort study |
title_full | Clinicopathologic characteristics in patients with upper third gastric cancer following radical surgical treatment: A retrospective cohort study |
title_fullStr | Clinicopathologic characteristics in patients with upper third gastric cancer following radical surgical treatment: A retrospective cohort study |
title_full_unstemmed | Clinicopathologic characteristics in patients with upper third gastric cancer following radical surgical treatment: A retrospective cohort study |
title_short | Clinicopathologic characteristics in patients with upper third gastric cancer following radical surgical treatment: A retrospective cohort study |
title_sort | clinicopathologic characteristics in patients with upper third gastric cancer following radical surgical treatment: a retrospective cohort study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250511/ https://www.ncbi.nlm.nih.gov/pubmed/30407293 http://dx.doi.org/10.1097/MD.0000000000013017 |
work_keys_str_mv | AT maxiaoming clinicopathologiccharacteristicsinpatientswithupperthirdgastriccancerfollowingradicalsurgicaltreatmentaretrospectivecohortstudy AT zhouwei clinicopathologiccharacteristicsinpatientswithupperthirdgastriccancerfollowingradicalsurgicaltreatmentaretrospectivecohortstudy AT wangcheng clinicopathologiccharacteristicsinpatientswithupperthirdgastriccancerfollowingradicalsurgicaltreatmentaretrospectivecohortstudy AT miaowei clinicopathologiccharacteristicsinpatientswithupperthirdgastriccancerfollowingradicalsurgicaltreatmentaretrospectivecohortstudy AT liuning clinicopathologiccharacteristicsinpatientswithupperthirdgastriccancerfollowingradicalsurgicaltreatmentaretrospectivecohortstudy AT wangshigui clinicopathologiccharacteristicsinpatientswithupperthirdgastriccancerfollowingradicalsurgicaltreatmentaretrospectivecohortstudy AT guanshihao clinicopathologiccharacteristicsinpatientswithupperthirdgastriccancerfollowingradicalsurgicaltreatmentaretrospectivecohortstudy |