Genetic polymorphism (rs6776158) in CaSR gene is associated with risk of nephrolithiasis in Chinese population

The objective of this study is to find about the association between calcium-sensing receptor (CaSR) genetic variants and susceptibility to nephrolithiasis in the Chinese Han population. This hospital-based case-control study included 319 nephrolithiasis cases and 378 healthy controls subjects. Two...

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Detalles Bibliográficos
Autores principales: Zhou, Hai, Huang, Huaxing, You, Zebin, Shadhu, Kamleshsingh, Ramlagun, Dadhija, Qiang, Cao, Li, Pu, Qi, Lezhong, Shen, Yuyong, Zhou, Ming, Chen, Yuming, Fei, Shangchun, Wang, Xiaoxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250535/
https://www.ncbi.nlm.nih.gov/pubmed/30407299
http://dx.doi.org/10.1097/MD.0000000000013037
Descripción
Sumario:The objective of this study is to find about the association between calcium-sensing receptor (CaSR) genetic variants and susceptibility to nephrolithiasis in the Chinese Han population. This hospital-based case-control study included 319 nephrolithiasis cases and 378 healthy controls subjects. Two SNPs in CaSR were genotyped using the TaqMan assay. We found that subjects carrying the G allele of rs6776158 (AG and GG) had significantly higher risk of nephrolithiasis compared to the AA genotype (P = .015 and .009, respectively). Our results indicate that rs6776158 polymorphism that might elevate the risk of nephrolithiasis in the Chinese population.

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