Genetic polymorphism (rs6776158) in CaSR gene is associated with risk of nephrolithiasis in Chinese population

The objective of this study is to find about the association between calcium-sensing receptor (CaSR) genetic variants and susceptibility to nephrolithiasis in the Chinese Han population. This hospital-based case-control study included 319 nephrolithiasis cases and 378 healthy controls subjects. Two...

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Autores principales: Zhou, Hai, Huang, Huaxing, You, Zebin, Shadhu, Kamleshsingh, Ramlagun, Dadhija, Qiang, Cao, Li, Pu, Qi, Lezhong, Shen, Yuyong, Zhou, Ming, Chen, Yuming, Fei, Shangchun, Wang, Xiaoxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
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Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250535/
https://www.ncbi.nlm.nih.gov/pubmed/30407299
http://dx.doi.org/10.1097/MD.0000000000013037
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author Zhou, Hai
Huang, Huaxing
You, Zebin
Shadhu, Kamleshsingh
Ramlagun, Dadhija
Qiang, Cao
Li, Pu
Qi, Lezhong
Shen, Yuyong
Zhou, Ming
Chen, Yuming
Fei, Shangchun
Wang, Xiaoxiang
author_facet Zhou, Hai
Huang, Huaxing
You, Zebin
Shadhu, Kamleshsingh
Ramlagun, Dadhija
Qiang, Cao
Li, Pu
Qi, Lezhong
Shen, Yuyong
Zhou, Ming
Chen, Yuming
Fei, Shangchun
Wang, Xiaoxiang
author_sort Zhou, Hai
collection PubMed
description The objective of this study is to find about the association between calcium-sensing receptor (CaSR) genetic variants and susceptibility to nephrolithiasis in the Chinese Han population. This hospital-based case-control study included 319 nephrolithiasis cases and 378 healthy controls subjects. Two SNPs in CaSR were genotyped using the TaqMan assay. We found that subjects carrying the G allele of rs6776158 (AG and GG) had significantly higher risk of nephrolithiasis compared to the AA genotype (P = .015 and .009, respectively). Our results indicate that rs6776158 polymorphism that might elevate the risk of nephrolithiasis in the Chinese population.
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spelling pubmed-62505352018-12-10 Genetic polymorphism (rs6776158) in CaSR gene is associated with risk of nephrolithiasis in Chinese population Zhou, Hai Huang, Huaxing You, Zebin Shadhu, Kamleshsingh Ramlagun, Dadhija Qiang, Cao Li, Pu Qi, Lezhong Shen, Yuyong Zhou, Ming Chen, Yuming Fei, Shangchun Wang, Xiaoxiang Medicine (Baltimore) Research Article The objective of this study is to find about the association between calcium-sensing receptor (CaSR) genetic variants and susceptibility to nephrolithiasis in the Chinese Han population. This hospital-based case-control study included 319 nephrolithiasis cases and 378 healthy controls subjects. Two SNPs in CaSR were genotyped using the TaqMan assay. We found that subjects carrying the G allele of rs6776158 (AG and GG) had significantly higher risk of nephrolithiasis compared to the AA genotype (P = .015 and .009, respectively). Our results indicate that rs6776158 polymorphism that might elevate the risk of nephrolithiasis in the Chinese population. Wolters Kluwer Health 2018-11-09 /pmc/articles/PMC6250535/ /pubmed/30407299 http://dx.doi.org/10.1097/MD.0000000000013037 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle Research Article
Zhou, Hai
Huang, Huaxing
You, Zebin
Shadhu, Kamleshsingh
Ramlagun, Dadhija
Qiang, Cao
Li, Pu
Qi, Lezhong
Shen, Yuyong
Zhou, Ming
Chen, Yuming
Fei, Shangchun
Wang, Xiaoxiang
Genetic polymorphism (rs6776158) in CaSR gene is associated with risk of nephrolithiasis in Chinese population
title Genetic polymorphism (rs6776158) in CaSR gene is associated with risk of nephrolithiasis in Chinese population
title_full Genetic polymorphism (rs6776158) in CaSR gene is associated with risk of nephrolithiasis in Chinese population
title_fullStr Genetic polymorphism (rs6776158) in CaSR gene is associated with risk of nephrolithiasis in Chinese population
title_full_unstemmed Genetic polymorphism (rs6776158) in CaSR gene is associated with risk of nephrolithiasis in Chinese population
title_short Genetic polymorphism (rs6776158) in CaSR gene is associated with risk of nephrolithiasis in Chinese population
title_sort genetic polymorphism (rs6776158) in casr gene is associated with risk of nephrolithiasis in chinese population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250535/
https://www.ncbi.nlm.nih.gov/pubmed/30407299
http://dx.doi.org/10.1097/MD.0000000000013037
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