Inhibiting Amyloid-ß cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design

Inhibiting the interaction between ß-amyloid (Aß) and a neuronal cell surface receptor, LilrB2, has been suggested as a potential route for treating Alzheimer’s disease (AD). Supporting this approach, AD-like symptoms are reduced in mouse models following genetic depletion of the LilrB2 homolog. In...

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Detalles Bibliográficos
Autores principales: Cao, Qin, Shin, Woo Shik, Chan, Henry, Vuong, Celine K., Dubois, Bethany, Li, Binsen, Sawaya, Michael R., Feigon, Juli, Black, Douglas L., Eisenberg, David S., Jiang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250578/
https://www.ncbi.nlm.nih.gov/pubmed/30297750
http://dx.doi.org/10.1038/s41557-018-0147-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250578/
https://www.ncbi.nlm.nih.gov/pubmed/30297750
http://dx.doi.org/10.1038/s41557-018-0147-z

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