Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy

Chemo-resistance is one of the major causes of cancer-related deaths. Here we used single-cell transcriptomics to investigate divergent modes of chemo-resistance in tumor cells. We observed that higher degree of phenotypic intra-tumor heterogeneity (ITH) favors selection of pre-existing drug-resista...

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Detalles Bibliográficos
Autores principales: Sharma, Ankur, Cao, Elaine Yiqun, Kumar, Vibhor, Zhang, Xiaoqian, Leong, Hui Sun, Wong, Angeline Mei Lin, Ramakrishnan, Neeraja, Hakimullah, Muhammad, Teo, Hui Min Vivian, Chong, Fui Teen, Chia, Shumei, Thangavelu, Matan Thangavelu, Kwang, Xue Lin, Gupta, Ruta, Clark, Jonathan R., Periyasamy, Giridharan, Iyer, N. Gopalakrishna, DasGupta, Ramanuj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250721/
https://www.ncbi.nlm.nih.gov/pubmed/30467425
http://dx.doi.org/10.1038/s41467-018-07261-3

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