Cargando…

The Early Phases of Ankylosing Spondylitis: Emerging Insights From Clinical and Basic Science

In our paper, we discuss how the early phases of ankylosing spondylitis (AS) are linked to peri-firbocartilagenous osteitis in the sacroiliac joint and entheseal bone related anchoring sites. This skeletal proclivity is linked to an abnormal immunological response to skeletal biomechanical stress an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Watad, Abdulla, Bridgewood, Charlie, Russell, Tobias, Marzo-Ortega, Helena, Cuthbert, Richard, McGonagle, Dennis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250731/ https://www.ncbi.nlm.nih.gov/pubmed/30505307 http://dx.doi.org/10.3389/fimmu.2018.02668

Ejemplares similares

Why Inhibition of IL-23 Lacked Efficacy in Ankylosing Spondylitis
por: McGonagle, Dennis, et al.
Publicado: (2021)

Sex-Based Medicine Meets Psoriatic Arthritis: Lessons Learned and to Learn
por: Bragazzi, Nicola Luigi, et al.
Publicado: (2022)

Harnessing Big Data, Smart and Digital Technologies and Artificial Intelligence for Preventing, Early Intercepting, Managing, and Treating Psoriatic Arthritis: Insights From a Systematic Review of the Literature
por: Bragazzi, Nicola Luigi, et al.
Publicado: (2022)

The IL-23p19/EBI3 heterodimeric cytokine termed IL-39 remains a theoretical cytokine in man
por: Bridgewood, Charlie, et al.
Publicado: (2019)

Severe COVID-19 as a virus-independent immunothrombotic process – Authors' reply
por: McGonagle, Dennis, et al.
Publicado: (2022)

Identification of myeloid cells in the human enthesis as the main source of local IL-23 production
por: Bridgewood, Charlie, et al.
Publicado: (2019)

COVID-19: angiotensin II in development of lung immunothrombosis and vasculitis mimics – Author's reply
por: McGonagle, Dennis, et al.
Publicado: (2021)

COVID-19 vasculitis and novel vasculitis mimics
por: McGonagle, Dennis, et al.
Publicado: (2021)

Evidence that tissue resident human enthesis γδT-cells can produce IL-17A independently of IL-23R transcript expression
por: Cuthbert, Richard James, et al.
Publicado: (2019)

IL-17A and TNF Modulate Normal Human Spinal Entheseal Bone and Soft Tissue Mesenchymal Stem Cell Osteogenesis, Adipogenesis, and Stromal Function
por: Russell, Tobias, et al.
Publicado: (2021)

The Immunological Impact of IL-1 Family Cytokines on the Epidermal Barrier
por: Macleod, Tom, et al.
Publicado: (2021)

Enthesitis: Much More Than Focal Insertion Point Inflammation
por: Watad, Abdulla, et al.
Publicado: (2018)

SARS-CoV-2 Infection Induces Psoriatic Arthritis Flares and Enthesis Resident Plasmacytoid Dendritic Cell Type-1 Interferon Inhibition by JAK Antagonism Offer Novel Spondyloarthritis Pathogenesis Insights
por: Zhou, Qiao, et al.
Publicado: (2021)

FMF Is Associated With a Wide Spectrum of MHC Class I- and Allied SpA Disorders but Not With Classical MHC Class II-Associated Autoimmune Disease: Insights From a Large Cohort Study
por: Watad, Abdulla, et al.
Publicado: (2019)

Cytokine “fine tuning” of enthesis tissue homeostasis as a pointer to spondyloarthritis pathogenesis with a focus on relevant TNF and IL-17 targeted therapies
por: Russell, Tobias, et al.
Publicado: (2021)

Immune cartography of macrophage activation syndrome in the COVID-19 era
por: McGonagle, Dennis, et al.
Publicado: (2021)

Therapeutic implications of ongoing alveolar viral replication in COVID-19
por: McGonagle, Dennis, et al.
Publicado: (2022)

Intestinal and enthesis innate immunity in early axial spondyloarthropathy
por: Sharif, Kassem, et al.
Publicado: (2020)

Corrigendum to: Intestinal and enthesis innate immunity in early axial spondyloarthropathy
por: Sharif, Kassem, et al.
Publicado: (2020)

Time to move away from an oxygen-centric model of pulmonary infarction? – Authors' reply
por: McGonagle, Dennis, et al.
Publicado: (2021)

A tricompartmental model of lung oxygenation disruption to explain pulmonary and systemic pathology in severe COVID-19
por: McGonagle, Dennis, et al.
Publicado: (2021)

Re: Patiently waiting for the results of anti-IL 6 therapy in severe COVID-19 infection
por: McGonagle, Dennis, et al.
Publicado: (2020)

The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease
por: McGonagle, Dennis, et al.
Publicado: (2020)

Perspectives on the Genetic Associations of Ankylosing Spondylitis
por: Wordsworth, B. Paul, et al.
Publicado: (2021)

Role of the microbiome and its metabolites in ankylosing spondylitis
por: Song, Zi-Yi, et al.
Publicado: (2022)

Joint together: The etiology and pathogenesis of ankylosing spondylitis
por: Xiong, Yuehan, et al.
Publicado: (2022)

Peptidomics analysis of plasma in patients with ankylosing spondylitis
por: Zhang, Guo-ning, et al.
Publicado: (2023)

Alterations in the gut virome in patients with ankylosing spondylitis
por: Li, Chen, et al.
Publicado: (2023)

Serum DKK-1 level in ankylosing spondylitis: insights from meta-analysis and Mendelian randomization
por: Fang, Xi, et al.
Publicado: (2023)

Editorial: Ankylosing Spondylitis and Related Immune-Mediated Disorders
por: Fiorillo, Maria Teresa, et al.
Publicado: (2019)

Editorial: Advances in Pathogenesis, Etiology, and Therapies for Ankylosing Spondylitis
por: Chen, Chih-Wei, et al.
Publicado: (2021)

Genetically predicted ankylosing spondylitis is causally associated with psoriasis
por: Tian, Di, et al.
Publicado: (2023)

Mechanisms of Immunothrombosis in Vaccine-Induced Thrombotic Thrombocytopenia (VITT) Compared to Natural SARS-CoV-2 Infection
por: McGonagle, Dennis, et al.
Publicado: (2021)

The Impact of Intermittent Fasting (Ramadan Fasting) on Psoriatic Arthritis Disease Activity, Enthesitis, and Dactylitis: A Multicentre Study
por: Adawi, Mohammad, et al.
Publicado: (2019)

Chest pain mimicking pulmonary embolism may be a common presentation of COVID‐19 in ambulant patients without other typical features of infection
por: Harrison, S. R., et al.
Publicado: (2021)

Cost Effectiveness of Secukinumab for the Treatment of Active Ankylosing Spondylitis in the UK
por: Emery, Paul, et al.
Publicado: (2018)

Characterization of Blood Mucosal‐Associated Invariant T Cells in Patients With Axial Spondyloarthritis and of Resident Mucosal‐Associated Invariant T Cells From the Axial Entheses of Non‐Axial Spondyloarthritis Control Patients
por: Rosine, Nicolas, et al.
Publicado: (2022)

Changes in ankylosing spondylitis incidence, prevalence and time to diagnosis over two decades
por: Crossfield, Samantha S R, et al.
Publicado: (2021)

GM-CSF Primes Proinflammatory Monocyte Responses in Ankylosing Spondylitis
por: Shi, Hui, et al.
Publicado: (2020)

Adalimumab Therapy Restores the Gut Microbiota in Patients With Ankylosing Spondylitis
por: Chen, Zena, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_6ds7ch065dq6j0bqmess5v8l4m