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DNA-PK Is Targeted by Multiple Vaccinia Virus Proteins to Inhibit DNA Sensing

Virus infection is sensed by pattern recognition receptors (PRRs) detecting virus nucleic acids and initiating an innate immune response. DNA-dependent protein kinase (DNA-PK) is a PRR that binds cytosolic DNA and is antagonized by vaccinia virus (VACV) protein C16. Here, VACV protein C4 is also sho...

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Detalles Bibliográficos
Autores principales:	Scutts, Simon R., Ember, Stuart W., Ren, Hongwei, Ye, Chao, Lovejoy, Christopher A., Mazzon, Michela, Veyer, David L., Sumner, Rebecca P., Smith, Geoffrey L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250978/ https://www.ncbi.nlm.nih.gov/pubmed/30428360 http://dx.doi.org/10.1016/j.celrep.2018.10.034

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