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Roles of TRAF6 in Central Nervous System
Tumor necrosis factor receptor-associated factor (TRAF) is an important binding protein of tumor necrosis factor (TNF) superfamily and the toll/IL-1 receptor (TIR) superfamily, which play an important role in innate immunity and ac-quired immunity. TRAFs family have 7 members (TRAF1-7), and TRAF6 ha...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Bentham Science Publishers
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251041/ https://www.ncbi.nlm.nih.gov/pubmed/29651950 http://dx.doi.org/10.2174/1570159X16666180412094655 |
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author | Dou, Yang Tian, Xiaodi Zhang, Jian Wang, Zhong Chen, Gang |
author_facet | Dou, Yang Tian, Xiaodi Zhang, Jian Wang, Zhong Chen, Gang |
author_sort | Dou, Yang |
collection | PubMed |
description | Tumor necrosis factor receptor-associated factor (TRAF) is an important binding protein of tumor necrosis factor (TNF) superfamily and the toll/IL-1 receptor (TIR) superfamily, which play an important role in innate immunity and ac-quired immunity. TRAFs family have 7 members (TRAF1-7), and TRAF6 has its special facture and biological function. TRAF6 has two special domains: C-terminal domain and N-terminal domain, which could integrate with multiple kinases and regulate signaling pathway function as an E3 ubiquitin ligase. Studies have increasingly found that TRAF6 is closely re-lated to central nervous system diseases, such as stroke, Traumatic brain injury, neurodegenerative diseases and neuropathic pain. Further research on the pathophysiological mechanism may be expected to become the new targets for the treatment of central nervous system diseases |
format | Online Article Text |
id | pubmed-6251041 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-62510412019-05-01 Roles of TRAF6 in Central Nervous System Dou, Yang Tian, Xiaodi Zhang, Jian Wang, Zhong Chen, Gang Curr Neuropharmacol Article Tumor necrosis factor receptor-associated factor (TRAF) is an important binding protein of tumor necrosis factor (TNF) superfamily and the toll/IL-1 receptor (TIR) superfamily, which play an important role in innate immunity and ac-quired immunity. TRAFs family have 7 members (TRAF1-7), and TRAF6 has its special facture and biological function. TRAF6 has two special domains: C-terminal domain and N-terminal domain, which could integrate with multiple kinases and regulate signaling pathway function as an E3 ubiquitin ligase. Studies have increasingly found that TRAF6 is closely re-lated to central nervous system diseases, such as stroke, Traumatic brain injury, neurodegenerative diseases and neuropathic pain. Further research on the pathophysiological mechanism may be expected to become the new targets for the treatment of central nervous system diseases Bentham Science Publishers 2018-11 2018-11 /pmc/articles/PMC6251041/ /pubmed/29651950 http://dx.doi.org/10.2174/1570159X16666180412094655 Text en © 2018 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Dou, Yang Tian, Xiaodi Zhang, Jian Wang, Zhong Chen, Gang Roles of TRAF6 in Central Nervous System |
title | Roles of TRAF6 in Central Nervous System |
title_full | Roles of TRAF6 in Central Nervous System |
title_fullStr | Roles of TRAF6 in Central Nervous System |
title_full_unstemmed | Roles of TRAF6 in Central Nervous System |
title_short | Roles of TRAF6 in Central Nervous System |
title_sort | roles of traf6 in central nervous system |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251041/ https://www.ncbi.nlm.nih.gov/pubmed/29651950 http://dx.doi.org/10.2174/1570159X16666180412094655 |
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