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Immune-related lichenoid mucocutaneous erosions during anti-PD-1 immunotherapy in metastatic renal cell carcinoma - A case report

Nivolumab belongs to the standard treatment options in metastatic renal cell carcinoma. Despite promising responses, a new spectrum of “immune-related” adverse effects has to be managed in daily clinical practice. A 74-year-old patient was treated with nivolumab in fourth-line. After 18 cycles, trea...

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Autores principales: Lindner, Andrea Katharina, Schachtner, Gert, Tulchiner, Gennadi, Staudacher, Nina, Steinkohl, Fabian, Nguyen, Van Anh, Horninger, Wolfgang, Pichler, Renate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251064/
https://www.ncbi.nlm.nih.gov/pubmed/30505683
http://dx.doi.org/10.1016/j.eucr.2018.11.008
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author Lindner, Andrea Katharina
Schachtner, Gert
Tulchiner, Gennadi
Staudacher, Nina
Steinkohl, Fabian
Nguyen, Van Anh
Horninger, Wolfgang
Pichler, Renate
author_facet Lindner, Andrea Katharina
Schachtner, Gert
Tulchiner, Gennadi
Staudacher, Nina
Steinkohl, Fabian
Nguyen, Van Anh
Horninger, Wolfgang
Pichler, Renate
author_sort Lindner, Andrea Katharina
collection PubMed
description Nivolumab belongs to the standard treatment options in metastatic renal cell carcinoma. Despite promising responses, a new spectrum of “immune-related” adverse effects has to be managed in daily clinical practice. A 74-year-old patient was treated with nivolumab in fourth-line. After 18 cycles, treatment was stopped due to severe adverse mucocutaneous reactions confirming a lichen ruber pemphigoides. CT scans during treatment discontinuation show stable disease since more than 14 months. Immunotherapy can cause mucocutaneous immune-mediated adverse reactions. The time of onset to cutaneous adverse effects is variable. Early recognition and treatment are essential in mitigating the severity of those adverse events.
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spelling pubmed-62510642018-11-30 Immune-related lichenoid mucocutaneous erosions during anti-PD-1 immunotherapy in metastatic renal cell carcinoma - A case report Lindner, Andrea Katharina Schachtner, Gert Tulchiner, Gennadi Staudacher, Nina Steinkohl, Fabian Nguyen, Van Anh Horninger, Wolfgang Pichler, Renate Urol Case Rep Oncology Nivolumab belongs to the standard treatment options in metastatic renal cell carcinoma. Despite promising responses, a new spectrum of “immune-related” adverse effects has to be managed in daily clinical practice. A 74-year-old patient was treated with nivolumab in fourth-line. After 18 cycles, treatment was stopped due to severe adverse mucocutaneous reactions confirming a lichen ruber pemphigoides. CT scans during treatment discontinuation show stable disease since more than 14 months. Immunotherapy can cause mucocutaneous immune-mediated adverse reactions. The time of onset to cutaneous adverse effects is variable. Early recognition and treatment are essential in mitigating the severity of those adverse events. Elsevier 2018-11-15 /pmc/articles/PMC6251064/ /pubmed/30505683 http://dx.doi.org/10.1016/j.eucr.2018.11.008 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Oncology
Lindner, Andrea Katharina
Schachtner, Gert
Tulchiner, Gennadi
Staudacher, Nina
Steinkohl, Fabian
Nguyen, Van Anh
Horninger, Wolfgang
Pichler, Renate
Immune-related lichenoid mucocutaneous erosions during anti-PD-1 immunotherapy in metastatic renal cell carcinoma - A case report
title Immune-related lichenoid mucocutaneous erosions during anti-PD-1 immunotherapy in metastatic renal cell carcinoma - A case report
title_full Immune-related lichenoid mucocutaneous erosions during anti-PD-1 immunotherapy in metastatic renal cell carcinoma - A case report
title_fullStr Immune-related lichenoid mucocutaneous erosions during anti-PD-1 immunotherapy in metastatic renal cell carcinoma - A case report
title_full_unstemmed Immune-related lichenoid mucocutaneous erosions during anti-PD-1 immunotherapy in metastatic renal cell carcinoma - A case report
title_short Immune-related lichenoid mucocutaneous erosions during anti-PD-1 immunotherapy in metastatic renal cell carcinoma - A case report
title_sort immune-related lichenoid mucocutaneous erosions during anti-pd-1 immunotherapy in metastatic renal cell carcinoma - a case report
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251064/
https://www.ncbi.nlm.nih.gov/pubmed/30505683
http://dx.doi.org/10.1016/j.eucr.2018.11.008
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