Tonic ATP-mediated growth suppression in peripheral nerve glia requires arrestin-PP2 and is evaded in NF1

Normal Schwann cells (SCs) are quiescent in adult nerves, when ATP is released from the nerve in an activity dependent manner. We find that suppressing nerve activity in adult nerves causes SC to enter the cell cycle. In vitro, ATP activates the SC G-protein coupled receptor (GPCR) P2Y2. Downstream...

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Detalles Bibliográficos
Autores principales: Coover, Robert A., Healy, Tabitha E., Guo, Li, Chaney, Katherine E., Hennigan, Robert F., Thomson, Craig S., Aschbacher-Smith, Lindsey E., Jankowski, Michael P., Ratner, Nancy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251093/
https://www.ncbi.nlm.nih.gov/pubmed/30470263
http://dx.doi.org/10.1186/s40478-018-0635-9

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