Cargando…

Electrocardiogram phenotypes in hypertrophic cardiomyopathy caused by distinct mechanisms: apico-basal repolarization gradients vs. Purkinje-myocardial coupling abnormalities

AIMS: To identify key structural and electrophysiological features explaining distinct electrocardiogram (ECG) phenotypes in hypertrophic cardiomyopathy (HCM). METHODS AND RESULTS: Human heart–torso anatomical models were constructed from cardiac magnetic resonance (CMR) images of HCM patients, repr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lyon, Aurore, Bueno-Orovio, Alfonso, Zacur, Ernesto, Ariga, Rina, Grau, Vicente, Neubauer, Stefan, Watkins, Hugh, Rodriguez, Blanca, Mincholé, Ana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251182/ https://www.ncbi.nlm.nih.gov/pubmed/30476051 http://dx.doi.org/10.1093/europace/euy226

Ejemplares similares

MRI-Based Computational Torso/Biventricular Multiscale Models to Investigate the Impact of Anatomical Variability on the ECG QRS Complex
por: Mincholé, Ana, et al.
Publicado: (2019)

Distinct ECG Phenotypes Identified in Hypertrophic Cardiomyopathy Using Machine Learning Associate With Arrhythmic Risk Markers
por: Lyon, Aurore, et al.
Publicado: (2018)

Improving the clinical understanding of hypertrophic cardiomyopathy by combining patient data, machine learning and computer simulations: A case study
por: Lyon, A., et al.
Publicado: (2019)

Early afterdepolarizations promote transmural reentry in ischemic human ventricles with reduced repolarization reserve
por: Dutta, Sara, et al.
Publicado: (2016)

Abnormality of apico–basal polarity in adenocarcinoma
por: Onuma, Kunishige, et al.
Publicado: (2022)

Fractional diffusion models of cardiac electrical propagation: role of structural heterogeneity in dispersion of repolarization
por: Bueno-Orovio, Alfonso, et al.
Publicado: (2014)

Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy
por: Passini, Elisa, et al.
Publicado: (2016)

Dbnl and β-catenin promote pro-N-cadherin processing to maintain apico-basal polarity
por: Herrera, Antonio, et al.
Publicado: (2021)

Septin 9 Orients the Apico–Basal Polarity Axis and Controls Plasticity Signals
por: Cai, Tingting, et al.
Publicado: (2023)

Apico-basal cell compression regulates Lamin A/C levels in epithelial tissues
por: Iyer, K. Venkatesan, et al.
Publicado: (2021)

Atrial Fibrillation Dynamics and Ionic Block Effects in Six Heterogeneous Human 3D Virtual Atria with Distinct Repolarization Dynamics
por: Sánchez, Carlos, et al.
Publicado: (2017)

High arrhythmic risk in antero-septal acute myocardial ischemia is explained by increased transmural reentry occurrence
por: Martinez-Navarro, Hector, et al.
Publicado: (2019)

Multiple roles for keratin intermediate filaments in the regulation of epithelial barrier function and apico-basal polarity
por: Salas, Pedro J., et al.
Publicado: (2016)

Dynamic apico-basal enrichment of the F-actin during cytokinesis in Arabidopsis cells embedded in their tissues
por: Lebecq, Alexis, et al.
Publicado: (2022)

Left ventricular anatomy in obstructive hypertrophic cardiomyopathy: beyond basal septal hypertrophy
por: Hermida, Uxio, et al.
Publicado: (2022)

Human ventricular activation sequence and the simulation of the electrocardiographic QRS complex and its variability in healthy and intraventricular block conditions
por: Cardone-Noott, Louie, et al.
Publicado: (2016)

Rab35 GTPase couples cell division with initiation of epithelial apico-basal polarity and lumen opening
por: Klinkert, Kerstin, et al.
Publicado: (2016)

The Electrogenic Na(+)/K(+) Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study
por: Britton, Oliver J., et al.
Publicado: (2017)

Corrigendum: The Electrogenic Na(+)/K(+) Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study
por: Britton, Oliver J., et al.
Publicado: (2017)

In Vivo and In Silico Investigation Into Mechanisms of Frequency Dependence of Repolarization Alternans in Human Ventricular Cardiomyocytes
por: Zhou, Xin, et al.
Publicado: (2016)

High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened
por: Gonçalves Antunes, Marina, et al.
Publicado: (2022)

Molecular basis of Tick Born encephalitis virus NS5 mediated subversion of apico-basal cell polarity signalling
por: Javorsky, Airah, et al.
Publicado: (2022)

The effects of acidosis and bicarbonate on action potential repolarization in canine cardiac Purkinje fibers
Publicado: (1979)

Basis for the Induction of Tissue-Level Phase-2 Reentry as a Repolarization Disorder in the Brugada Syndrome
por: Bueno-Orovio, Alfonso, et al.
Publicado: (2015)

In-silico drug trials for precision medicine in atrial fibrillation: From ionic mechanisms to electrocardiogram-based predictions in structurally-healthy human atria
por: Dasí, Albert, et al.
Publicado: (2022)

ApicoAlign: an alignment and sequence search tool for apicomplexan proteins
por: Ali, Jamshaid, et al.
Publicado: (2011)

Constitutive Active Mutant TIE2 Induces Enlarged Vascular Lumen Formation with Loss of Apico-basal Polarity and Pericyte Recruitment
por: Cai, Yuqi, et al.
Publicado: (2019)

Ninein is essential for apico-basal microtubule formation and CLIP-170 facilitates its redeployment to non-centrosomal microtubule organizing centres
por: Goldspink, Deborah A., et al.
Publicado: (2017)

ECG-based estimation of dispersion of APD restitution as a tool to stratify sotalol-induced arrhythmic risk
por: Mincholé, A., et al.
Publicado: (2015)

Left ventricular false tendons and electrocardiogram repolarization abnormalities in healthy young subjects
por: Lazarevic, Zlatan, et al.
Publicado: (2016)

Apico-basal Polarity Determinants Encoded by crumbs Genes Affect Ciliary Shaft Protein Composition, IFT Movement Dynamics, and Cilia Length
por: Hazime, Khodor, et al.
Publicado: (2017)

Reversed Apico-Basal Myocardial Relaxation Sequence During Exercise in Long QT Syndrome Mutations Carriers With History of Previous Cardiac Events
por: Charisopoulou, Dafni, et al.
Publicado: (2022)

Assessment of dynamic cardiac repolarization and contractility in patients with hypertrophic cardiomyopathy
por: Radbill, Andrew E., et al.
Publicado: (2021)

Role of the Purkinje-Muscle Junction on the Ventricular Repolarization Heterogeneity in the Healthy and Ischemic Ovine Ventricular Myocardium
por: Martinez, Marine E., et al.
Publicado: (2018)

Mechanisms and prognostic impact of myocardial ischaemia in hypertrophic cardiomyopathy
por: Coleman, James A., et al.
Publicado: (2023)

Identification of Myocardial Disarray in Patients With Hypertrophic Cardiomyopathy and Ventricular Arrhythmias
por: Ariga, Rina, et al.
Publicado: (2019)

Origami: Single-cell 3D shape dynamics oriented along the apico-basal axis of folding epithelia from fluorescence microscopy data
por: Mendonca, Tania, et al.
Publicado: (2021)

Right ventricular function declines prior to left ventricular ejection fraction in hypertrophic cardiomyopathy
por: Mahmod, Masliza, et al.
Publicado: (2022)

Midostaurin does not prolong cardiac repolarization defined in a thorough electrocardiogram trial in healthy volunteers
por: del Corral, Adam, et al.
Publicado: (2012)

Depolarization-repolarization synchrony after right ventricular and left bundle branch area pacing
por: Sales Belles, C, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_a44hjp90ielcpugs6fc5ra60k9