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Imprinted and ancient gene: a potential mediator of cancer cell survival during tryptophan deprivation

BACKGROUND: Depletion of tryptophan and the accumulation of tryptophan metabolites mediated by the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1), trigger immune cells to undergo apoptosis. However, cancer cells in the same microenvironment appear not to be affected. Mechanisms whereb...

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Detalles Bibliográficos
Autores principales:	Tomek, Petr, Gore, Shanti K., Potts, Chloe L., Print, Cristin G., Black, Michael A., Hallermayr, Ariane, Kilian, Michael, Sattlegger, Evelyn, Ching, Lai-Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251197/ https://www.ncbi.nlm.nih.gov/pubmed/30466445 http://dx.doi.org/10.1186/s12964-018-0301-7

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