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Effects of physiological aging factor on bone tissue engineering repair based on fetal BMSCs

BACKGROUND: At present, many laboratories and hospitals all over the world are attempting and exploring the clinical transformation of this tissue engineered bone graft (TEBG) strategy. Many successful cases of bone tissue engineering (BTE) repair were based on young individuals. But there are littl...

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Autores principales: Wu, Dingyu, Wang, Zhenxing, Zheng, Zhiwei, Geng, Yingnan, Zhang, Zhanzhao, Li, Qiannan, Zhou, Quan, Cao, Yilin, Zhang, Zhi-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251213/
https://www.ncbi.nlm.nih.gov/pubmed/30470235
http://dx.doi.org/10.1186/s12967-018-1686-1
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author Wu, Dingyu
Wang, Zhenxing
Zheng, Zhiwei
Geng, Yingnan
Zhang, Zhanzhao
Li, Qiannan
Zhou, Quan
Cao, Yilin
Zhang, Zhi-Yong
author_facet Wu, Dingyu
Wang, Zhenxing
Zheng, Zhiwei
Geng, Yingnan
Zhang, Zhanzhao
Li, Qiannan
Zhou, Quan
Cao, Yilin
Zhang, Zhi-Yong
author_sort Wu, Dingyu
collection PubMed
description BACKGROUND: At present, many laboratories and hospitals all over the world are attempting and exploring the clinical transformation of this tissue engineered bone graft (TEBG) strategy. Many successful cases of bone tissue engineering (BTE) repair were based on young individuals. But there are little studies about the effectiveness of TEBG strategy in physiological aged individuals. METHODS: In this research, we studied whether aging factor has influence on the skull repair effect of Fetal-TEBG, at the level of the large animal models. We used the fetal bone marrow stromal cells (Fetal-BMSCs) as the seed cells, combining the decalcified bone matrix (DBM) scaffolds, to repair the skull defects of the aged goats and the young goats. The repair effects on both aged goat and young goat were compared by Micro-CT and histology examination. RESULTS: The skull defects of the young goats could be repaired better than that of the aged goats after 6 months by Fetal-TEBG; In the aged goats, although not completely repaired, the defects repaired by Fetal-TEBG was better than that repaired by the Control DBM scaffold. CONCLUSIONS: Aging factor has impact on the bone repair effect of Fetal-TEBG; and the BTE strategy is still efficacious even in the aged individuals. The improvement of the aged state may promote the repair effect of the BTE in the aged individuals. [Image: see text]
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spelling pubmed-62512132018-11-29 Effects of physiological aging factor on bone tissue engineering repair based on fetal BMSCs Wu, Dingyu Wang, Zhenxing Zheng, Zhiwei Geng, Yingnan Zhang, Zhanzhao Li, Qiannan Zhou, Quan Cao, Yilin Zhang, Zhi-Yong J Transl Med Research BACKGROUND: At present, many laboratories and hospitals all over the world are attempting and exploring the clinical transformation of this tissue engineered bone graft (TEBG) strategy. Many successful cases of bone tissue engineering (BTE) repair were based on young individuals. But there are little studies about the effectiveness of TEBG strategy in physiological aged individuals. METHODS: In this research, we studied whether aging factor has influence on the skull repair effect of Fetal-TEBG, at the level of the large animal models. We used the fetal bone marrow stromal cells (Fetal-BMSCs) as the seed cells, combining the decalcified bone matrix (DBM) scaffolds, to repair the skull defects of the aged goats and the young goats. The repair effects on both aged goat and young goat were compared by Micro-CT and histology examination. RESULTS: The skull defects of the young goats could be repaired better than that of the aged goats after 6 months by Fetal-TEBG; In the aged goats, although not completely repaired, the defects repaired by Fetal-TEBG was better than that repaired by the Control DBM scaffold. CONCLUSIONS: Aging factor has impact on the bone repair effect of Fetal-TEBG; and the BTE strategy is still efficacious even in the aged individuals. The improvement of the aged state may promote the repair effect of the BTE in the aged individuals. [Image: see text] BioMed Central 2018-11-23 /pmc/articles/PMC6251213/ /pubmed/30470235 http://dx.doi.org/10.1186/s12967-018-1686-1 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Wu, Dingyu
Wang, Zhenxing
Zheng, Zhiwei
Geng, Yingnan
Zhang, Zhanzhao
Li, Qiannan
Zhou, Quan
Cao, Yilin
Zhang, Zhi-Yong
Effects of physiological aging factor on bone tissue engineering repair based on fetal BMSCs
title Effects of physiological aging factor on bone tissue engineering repair based on fetal BMSCs
title_full Effects of physiological aging factor on bone tissue engineering repair based on fetal BMSCs
title_fullStr Effects of physiological aging factor on bone tissue engineering repair based on fetal BMSCs
title_full_unstemmed Effects of physiological aging factor on bone tissue engineering repair based on fetal BMSCs
title_short Effects of physiological aging factor on bone tissue engineering repair based on fetal BMSCs
title_sort effects of physiological aging factor on bone tissue engineering repair based on fetal bmscs
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251213/
https://www.ncbi.nlm.nih.gov/pubmed/30470235
http://dx.doi.org/10.1186/s12967-018-1686-1
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