AMBIsome Therapy Induction OptimisatioN (AMBITION): High Dose AmBisome for Cryptococcal Meningitis Induction Therapy in sub-Saharan Africa: Study Protocol for a Phase 3 Randomised Controlled Non-Inferiority Trial

BACKGROUND: Cryptococcal meningitis (CM) is a major cause of mortality in HIV programmes in Africa despite increasing access to antiretroviral therapy (ART). Mortality is driven in part by limited availability of amphotericin-based treatment, drug-induced toxicities of amphotericin B deoxycholate an...

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Detalles Bibliográficos
Autores principales: Lawrence, David S., Youssouf, Nabila, Molloy, Síle L. F., Alanio, Alexandre, Alufandika, Melanie, Boulware, David R., Boyer-Chammard, Timothée, Chen, Tao, Dromer, Francoise, Hlupeni, Admire, Hope, William, Hosseinipour, Mina C., Kanyama, Cecilia, Lortholary, Oliver, Loyse, Angela, Meya, David B., Mosepele, Mosepele, Muzoora, Conrad, Mwandumba, Henry C., Ndhlovu, Chiratidzo E., Niessen, Louis, Schutz, Charlotte, Stott, Katharine E., Wang, Duolao, Lalloo, David G., Meintjes, Graeme, Jaffar, Shabbar, Harrison, Thomas S., Jarvis, Joseph N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251219/
https://www.ncbi.nlm.nih.gov/pubmed/30470259
http://dx.doi.org/10.1186/s13063-018-3026-4

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