Cargando…

Precision Medicine: Changing the way we think about healthcare

Health care has changed since the decline in mortality caused by infectious diseases as well as chronic and non-contagious diseases, with a direct impact on the cost of public health and individual health care. We must now transition from traditional reactive medicine based on symptoms, diagnosis an...

Descripción completa

Detalles Bibliográficos
Autores principales: Gameiro, Gustavo Rosa, Sinkunas, Viktor, Liguori, Gabriel Romero, Auler-Júnior, José Otavio Costa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251254/
https://www.ncbi.nlm.nih.gov/pubmed/30517307
http://dx.doi.org/10.6061/clinics/2017/e723
_version_ 1783373084517990400
author Gameiro, Gustavo Rosa
Sinkunas, Viktor
Liguori, Gabriel Romero
Auler-Júnior, José Otavio Costa
author_facet Gameiro, Gustavo Rosa
Sinkunas, Viktor
Liguori, Gabriel Romero
Auler-Júnior, José Otavio Costa
author_sort Gameiro, Gustavo Rosa
collection PubMed
description Health care has changed since the decline in mortality caused by infectious diseases as well as chronic and non-contagious diseases, with a direct impact on the cost of public health and individual health care. We must now transition from traditional reactive medicine based on symptoms, diagnosis and treatment to a system that targets the disease before it occurs and, if it cannot be avoided, treats the disease in a personalized manner. Precision Medicine is that new way of thinking about medicine. In this paper, we performed a thorough review of the literature to present an updated review on the subject, discussing the impact of the use of genetics and genomics in the care process as well as medical education, clinical research and ethical issues. The Precision Medicine model is expanded upon in this article to include its principles of prediction, prevention, personalization and participation. Finally, we discuss Precision Medicine in various specialty fields and how it has been implemented in developing countries and its effects on public health and medical education.
format Online
Article
Text
id pubmed-6251254
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
record_format MEDLINE/PubMed
spelling pubmed-62512542018-11-29 Precision Medicine: Changing the way we think about healthcare Gameiro, Gustavo Rosa Sinkunas, Viktor Liguori, Gabriel Romero Auler-Júnior, José Otavio Costa Clinics (Sao Paulo) Review Article Health care has changed since the decline in mortality caused by infectious diseases as well as chronic and non-contagious diseases, with a direct impact on the cost of public health and individual health care. We must now transition from traditional reactive medicine based on symptoms, diagnosis and treatment to a system that targets the disease before it occurs and, if it cannot be avoided, treats the disease in a personalized manner. Precision Medicine is that new way of thinking about medicine. In this paper, we performed a thorough review of the literature to present an updated review on the subject, discussing the impact of the use of genetics and genomics in the care process as well as medical education, clinical research and ethical issues. The Precision Medicine model is expanded upon in this article to include its principles of prediction, prevention, personalization and participation. Finally, we discuss Precision Medicine in various specialty fields and how it has been implemented in developing countries and its effects on public health and medical education. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2018-11-23 2018 /pmc/articles/PMC6251254/ /pubmed/30517307 http://dx.doi.org/10.6061/clinics/2017/e723 Text en Copyright © 2018 CLINICS http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited.
spellingShingle Review Article
Gameiro, Gustavo Rosa
Sinkunas, Viktor
Liguori, Gabriel Romero
Auler-Júnior, José Otavio Costa
Precision Medicine: Changing the way we think about healthcare
title Precision Medicine: Changing the way we think about healthcare
title_full Precision Medicine: Changing the way we think about healthcare
title_fullStr Precision Medicine: Changing the way we think about healthcare
title_full_unstemmed Precision Medicine: Changing the way we think about healthcare
title_short Precision Medicine: Changing the way we think about healthcare
title_sort precision medicine: changing the way we think about healthcare
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251254/
https://www.ncbi.nlm.nih.gov/pubmed/30517307
http://dx.doi.org/10.6061/clinics/2017/e723
work_keys_str_mv AT gameirogustavorosa precisionmedicinechangingthewaywethinkabouthealthcare
AT sinkunasviktor precisionmedicinechangingthewaywethinkabouthealthcare
AT liguorigabrielromero precisionmedicinechangingthewaywethinkabouthealthcare
AT aulerjuniorjoseotaviocosta precisionmedicinechangingthewaywethinkabouthealthcare