Cargando…

Effect of metal-containing topical agents on surface doses received during external irradiation

The ability of topical metal-containing agents (MCAs) to enhance radiation dermatitis remains controversial. In the present study, we evaluated increases in surface doses associated with topical agents at different application thicknesses and with MCAs versus non-metal containing agents (NMCAs). We...

Descripción completa

Detalles Bibliográficos
Autores principales: Iyama, Ayumi, Matsuyama, Tomohiko, Matsumoto, Eriko, Araki, Takafumi, Inokuchi, Satoshi, Yamashita, Mizuki, Honda, Noritoshi, Miyake, Taiga, Saito, Tetsuo, Toya, Ryo, Kai, Yudai, Yamashita, Yasuyuki, Oya, Natsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251421/
https://www.ncbi.nlm.nih.gov/pubmed/30247674
http://dx.doi.org/10.1093/jrr/rry078
_version_ 1783373118299963392
author Iyama, Ayumi
Matsuyama, Tomohiko
Matsumoto, Eriko
Araki, Takafumi
Inokuchi, Satoshi
Yamashita, Mizuki
Honda, Noritoshi
Miyake, Taiga
Saito, Tetsuo
Toya, Ryo
Kai, Yudai
Yamashita, Yasuyuki
Oya, Natsuo
author_facet Iyama, Ayumi
Matsuyama, Tomohiko
Matsumoto, Eriko
Araki, Takafumi
Inokuchi, Satoshi
Yamashita, Mizuki
Honda, Noritoshi
Miyake, Taiga
Saito, Tetsuo
Toya, Ryo
Kai, Yudai
Yamashita, Yasuyuki
Oya, Natsuo
author_sort Iyama, Ayumi
collection PubMed
description The ability of topical metal-containing agents (MCAs) to enhance radiation dermatitis remains controversial. In the present study, we evaluated increases in surface doses associated with topical agents at different application thicknesses and with MCAs versus non-metal containing agents (NMCAs). We assessed two clinically available MCAs, zinc oxide ointment (ZOO) and silver sulfadiazine cream (SSDC), and eight NMCAs. Surface doses were measured using a Markus chamber placed on a polystyrene phantom. To evaluate the role of application thickness, each agent was applied to the chamber in oil-slick (<0.1-mm), 1-mm and 5-mm layers prior to irradiation of a 10 × 10 cm field with 4-, 6- and 10-MV X-ray beams. The surface dose enhancement ratio (SDER) was calculated as the ratio of the surface dose with an agent to the dose without an agent. The SDER values for the eight NMCAs, ZOO and SSDC at an oil-slick thickness were 101.6–104.6% (mean: 103.3%), 104.5% and 105.0%, respectively, using a 6-MV X-ray beam. The corresponding values at a 1-mm thickness were 196.8–237.8% (mean: 215.7%), 229.3% and 201.4%, respectively, and those at a 5-mm thickness were 342.2–382.4% (mean: 357.9%), 357.1% and 352.6%, respectively. A similar tendency was found using 4- and 10-MV X-ray beams. The lack of a significant difference in surface dose enhancement between MCAs and NMCAs, particularly when applied in oil-slick layers, suggests that MCAs do not need to be avoided or applied in a restricted manner during radiotherapy for dosimetric reasons.
format Online
Article
Text
id pubmed-6251421
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-62514212018-11-28 Effect of metal-containing topical agents on surface doses received during external irradiation Iyama, Ayumi Matsuyama, Tomohiko Matsumoto, Eriko Araki, Takafumi Inokuchi, Satoshi Yamashita, Mizuki Honda, Noritoshi Miyake, Taiga Saito, Tetsuo Toya, Ryo Kai, Yudai Yamashita, Yasuyuki Oya, Natsuo J Radiat Res Regular Paper The ability of topical metal-containing agents (MCAs) to enhance radiation dermatitis remains controversial. In the present study, we evaluated increases in surface doses associated with topical agents at different application thicknesses and with MCAs versus non-metal containing agents (NMCAs). We assessed two clinically available MCAs, zinc oxide ointment (ZOO) and silver sulfadiazine cream (SSDC), and eight NMCAs. Surface doses were measured using a Markus chamber placed on a polystyrene phantom. To evaluate the role of application thickness, each agent was applied to the chamber in oil-slick (<0.1-mm), 1-mm and 5-mm layers prior to irradiation of a 10 × 10 cm field with 4-, 6- and 10-MV X-ray beams. The surface dose enhancement ratio (SDER) was calculated as the ratio of the surface dose with an agent to the dose without an agent. The SDER values for the eight NMCAs, ZOO and SSDC at an oil-slick thickness were 101.6–104.6% (mean: 103.3%), 104.5% and 105.0%, respectively, using a 6-MV X-ray beam. The corresponding values at a 1-mm thickness were 196.8–237.8% (mean: 215.7%), 229.3% and 201.4%, respectively, and those at a 5-mm thickness were 342.2–382.4% (mean: 357.9%), 357.1% and 352.6%, respectively. A similar tendency was found using 4- and 10-MV X-ray beams. The lack of a significant difference in surface dose enhancement between MCAs and NMCAs, particularly when applied in oil-slick layers, suggests that MCAs do not need to be avoided or applied in a restricted manner during radiotherapy for dosimetric reasons. Oxford University Press 2018-11 2018-09-22 /pmc/articles/PMC6251421/ /pubmed/30247674 http://dx.doi.org/10.1093/jrr/rry078 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Regular Paper
Iyama, Ayumi
Matsuyama, Tomohiko
Matsumoto, Eriko
Araki, Takafumi
Inokuchi, Satoshi
Yamashita, Mizuki
Honda, Noritoshi
Miyake, Taiga
Saito, Tetsuo
Toya, Ryo
Kai, Yudai
Yamashita, Yasuyuki
Oya, Natsuo
Effect of metal-containing topical agents on surface doses received during external irradiation
title Effect of metal-containing topical agents on surface doses received during external irradiation
title_full Effect of metal-containing topical agents on surface doses received during external irradiation
title_fullStr Effect of metal-containing topical agents on surface doses received during external irradiation
title_full_unstemmed Effect of metal-containing topical agents on surface doses received during external irradiation
title_short Effect of metal-containing topical agents on surface doses received during external irradiation
title_sort effect of metal-containing topical agents on surface doses received during external irradiation
topic Regular Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251421/
https://www.ncbi.nlm.nih.gov/pubmed/30247674
http://dx.doi.org/10.1093/jrr/rry078
work_keys_str_mv AT iyamaayumi effectofmetalcontainingtopicalagentsonsurfacedosesreceivedduringexternalirradiation
AT matsuyamatomohiko effectofmetalcontainingtopicalagentsonsurfacedosesreceivedduringexternalirradiation
AT matsumotoeriko effectofmetalcontainingtopicalagentsonsurfacedosesreceivedduringexternalirradiation
AT arakitakafumi effectofmetalcontainingtopicalagentsonsurfacedosesreceivedduringexternalirradiation
AT inokuchisatoshi effectofmetalcontainingtopicalagentsonsurfacedosesreceivedduringexternalirradiation
AT yamashitamizuki effectofmetalcontainingtopicalagentsonsurfacedosesreceivedduringexternalirradiation
AT hondanoritoshi effectofmetalcontainingtopicalagentsonsurfacedosesreceivedduringexternalirradiation
AT miyaketaiga effectofmetalcontainingtopicalagentsonsurfacedosesreceivedduringexternalirradiation
AT saitotetsuo effectofmetalcontainingtopicalagentsonsurfacedosesreceivedduringexternalirradiation
AT toyaryo effectofmetalcontainingtopicalagentsonsurfacedosesreceivedduringexternalirradiation
AT kaiyudai effectofmetalcontainingtopicalagentsonsurfacedosesreceivedduringexternalirradiation
AT yamashitayasuyuki effectofmetalcontainingtopicalagentsonsurfacedosesreceivedduringexternalirradiation
AT oyanatsuo effectofmetalcontainingtopicalagentsonsurfacedosesreceivedduringexternalirradiation