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Effect of metal-containing topical agents on surface doses received during external irradiation
The ability of topical metal-containing agents (MCAs) to enhance radiation dermatitis remains controversial. In the present study, we evaluated increases in surface doses associated with topical agents at different application thicknesses and with MCAs versus non-metal containing agents (NMCAs). We...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251421/ https://www.ncbi.nlm.nih.gov/pubmed/30247674 http://dx.doi.org/10.1093/jrr/rry078 |
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author | Iyama, Ayumi Matsuyama, Tomohiko Matsumoto, Eriko Araki, Takafumi Inokuchi, Satoshi Yamashita, Mizuki Honda, Noritoshi Miyake, Taiga Saito, Tetsuo Toya, Ryo Kai, Yudai Yamashita, Yasuyuki Oya, Natsuo |
author_facet | Iyama, Ayumi Matsuyama, Tomohiko Matsumoto, Eriko Araki, Takafumi Inokuchi, Satoshi Yamashita, Mizuki Honda, Noritoshi Miyake, Taiga Saito, Tetsuo Toya, Ryo Kai, Yudai Yamashita, Yasuyuki Oya, Natsuo |
author_sort | Iyama, Ayumi |
collection | PubMed |
description | The ability of topical metal-containing agents (MCAs) to enhance radiation dermatitis remains controversial. In the present study, we evaluated increases in surface doses associated with topical agents at different application thicknesses and with MCAs versus non-metal containing agents (NMCAs). We assessed two clinically available MCAs, zinc oxide ointment (ZOO) and silver sulfadiazine cream (SSDC), and eight NMCAs. Surface doses were measured using a Markus chamber placed on a polystyrene phantom. To evaluate the role of application thickness, each agent was applied to the chamber in oil-slick (<0.1-mm), 1-mm and 5-mm layers prior to irradiation of a 10 × 10 cm field with 4-, 6- and 10-MV X-ray beams. The surface dose enhancement ratio (SDER) was calculated as the ratio of the surface dose with an agent to the dose without an agent. The SDER values for the eight NMCAs, ZOO and SSDC at an oil-slick thickness were 101.6–104.6% (mean: 103.3%), 104.5% and 105.0%, respectively, using a 6-MV X-ray beam. The corresponding values at a 1-mm thickness were 196.8–237.8% (mean: 215.7%), 229.3% and 201.4%, respectively, and those at a 5-mm thickness were 342.2–382.4% (mean: 357.9%), 357.1% and 352.6%, respectively. A similar tendency was found using 4- and 10-MV X-ray beams. The lack of a significant difference in surface dose enhancement between MCAs and NMCAs, particularly when applied in oil-slick layers, suggests that MCAs do not need to be avoided or applied in a restricted manner during radiotherapy for dosimetric reasons. |
format | Online Article Text |
id | pubmed-6251421 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-62514212018-11-28 Effect of metal-containing topical agents on surface doses received during external irradiation Iyama, Ayumi Matsuyama, Tomohiko Matsumoto, Eriko Araki, Takafumi Inokuchi, Satoshi Yamashita, Mizuki Honda, Noritoshi Miyake, Taiga Saito, Tetsuo Toya, Ryo Kai, Yudai Yamashita, Yasuyuki Oya, Natsuo J Radiat Res Regular Paper The ability of topical metal-containing agents (MCAs) to enhance radiation dermatitis remains controversial. In the present study, we evaluated increases in surface doses associated with topical agents at different application thicknesses and with MCAs versus non-metal containing agents (NMCAs). We assessed two clinically available MCAs, zinc oxide ointment (ZOO) and silver sulfadiazine cream (SSDC), and eight NMCAs. Surface doses were measured using a Markus chamber placed on a polystyrene phantom. To evaluate the role of application thickness, each agent was applied to the chamber in oil-slick (<0.1-mm), 1-mm and 5-mm layers prior to irradiation of a 10 × 10 cm field with 4-, 6- and 10-MV X-ray beams. The surface dose enhancement ratio (SDER) was calculated as the ratio of the surface dose with an agent to the dose without an agent. The SDER values for the eight NMCAs, ZOO and SSDC at an oil-slick thickness were 101.6–104.6% (mean: 103.3%), 104.5% and 105.0%, respectively, using a 6-MV X-ray beam. The corresponding values at a 1-mm thickness were 196.8–237.8% (mean: 215.7%), 229.3% and 201.4%, respectively, and those at a 5-mm thickness were 342.2–382.4% (mean: 357.9%), 357.1% and 352.6%, respectively. A similar tendency was found using 4- and 10-MV X-ray beams. The lack of a significant difference in surface dose enhancement between MCAs and NMCAs, particularly when applied in oil-slick layers, suggests that MCAs do not need to be avoided or applied in a restricted manner during radiotherapy for dosimetric reasons. Oxford University Press 2018-11 2018-09-22 /pmc/articles/PMC6251421/ /pubmed/30247674 http://dx.doi.org/10.1093/jrr/rry078 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Regular Paper Iyama, Ayumi Matsuyama, Tomohiko Matsumoto, Eriko Araki, Takafumi Inokuchi, Satoshi Yamashita, Mizuki Honda, Noritoshi Miyake, Taiga Saito, Tetsuo Toya, Ryo Kai, Yudai Yamashita, Yasuyuki Oya, Natsuo Effect of metal-containing topical agents on surface doses received during external irradiation |
title | Effect of metal-containing topical agents on surface doses received during external irradiation |
title_full | Effect of metal-containing topical agents on surface doses received during external irradiation |
title_fullStr | Effect of metal-containing topical agents on surface doses received during external irradiation |
title_full_unstemmed | Effect of metal-containing topical agents on surface doses received during external irradiation |
title_short | Effect of metal-containing topical agents on surface doses received during external irradiation |
title_sort | effect of metal-containing topical agents on surface doses received during external irradiation |
topic | Regular Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251421/ https://www.ncbi.nlm.nih.gov/pubmed/30247674 http://dx.doi.org/10.1093/jrr/rry078 |
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