Structural basis of tubulin recruitment and assembly by microtubule polymerases with tumor overexpressed gene (TOG) domain arrays

XMAP215/Stu2/Alp14 proteins accelerate microtubule plus-end polymerization by recruiting tubulins via arrays of tumor overexpressed gene (TOG) domains, yet their mechanism remains unknown. Here, we describe the biochemical and structural basis for TOG arrays in recruiting and polymerizing tubulins....

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Detalles Bibliográficos
Autores principales: Nithianantham, Stanley, Cook, Brian D, Beans, Madeleine, Guo, Fei, Chang, Fred, Al-Bassam, Jawdat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251626/
https://www.ncbi.nlm.nih.gov/pubmed/30422110
http://dx.doi.org/10.7554/eLife.38922

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251626/
https://www.ncbi.nlm.nih.gov/pubmed/30422110
http://dx.doi.org/10.7554/eLife.38922

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