High-throughput screening for small molecule inhibitors of the type-I interferon signaling pathway

Interferons (IFNs) are cytokines with fundamental roles in resistance to infections, cancer and other diseases. Type-I IFNs, interferon α (IFN-α) and interferon β (IFN-β), act through a shared receptor complex (IFNAR) comprised of IFNAR1 and IFNAR2 subunits. Binding of type-I IFN to IFNAR1 will robu...

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Detalles Bibliográficos
Autores principales: Yuliantie, Elita, Dai, Xinchuan, Yang, Dehua, Crack, Peter J., Wang, Ming-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251811/
https://www.ncbi.nlm.nih.gov/pubmed/30505658
http://dx.doi.org/10.1016/j.apsb.2018.07.005

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