Cargando…

Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia

The epidemiologic link between schizophrenia (SCZ) and type 2 diabetes (T2D) remains poorly understood. Here, we investigate the presence and extent of a shared genetic background between SCZ and T2D using genome-wide approaches. We performed a genome-wide association study (GWAS) and polygenic risk...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hackinger, Sophie, Prins, Bram, Mamakou, Vasiliki, Zengini, Eleni, Marouli, Eirini, Brčić, Luka, Serafetinidis, Ioannis, Lamnissou, Klea, Kontaxakis, Vassilis, Dedoussis, George, Gonidakis, Fragiskos, Thanopoulou, Anastasia, Tentolouris, Nikolaos, Tsezou, Aspasia, Zeggini, Eleftheria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251918/ https://www.ncbi.nlm.nih.gov/pubmed/30470734 http://dx.doi.org/10.1038/s41398-018-0304-6

Ejemplares similares

Combination therapy as a potential risk factor for the development of type 2 diabetes in patients with schizophrenia: the GOMAP study
por: Mamakou, Vasiliki, et al.
Publicado: (2018)

Evaluating the glucose raising effect of established loci via a genetic risk score
por: Marouli, Eirini, et al.
Publicado: (2017)

A Dietary Pattern with High Sugar Content Is Associated with Cardiometabolic Risk Factors in the Pomak Population
por: Farmaki, Aliki-Eleni, et al.
Publicado: (2019)

Statistical methods to detect pleiotropy in human complex traits
por: Hackinger, Sophie, et al.
Publicado: (2017)

A novel variant in GLIS3 is associated with osteoarthritis
por: Casalone, Elisabetta, et al.
Publicado: (2018)

Exercise dependence and orthorexia nervosa in Crossfit: exploring the role of perfectionism
por: Mavrandrea, Panagiota, et al.
Publicado: (2022)

Leptin as a critical regulator of hepatocellular carcinoma development through modulation of human telomerase reverse transcriptase
por: Stefanou, Nikolaos, et al.
Publicado: (2010)

A 12-month study of dialectical behavioral therapy for bοrderline patients suffering from eating disorders
por: Liakopoulou, Efi, et al.
Publicado: (2023)

Genetic characterization of Greek population isolates reveals strong genetic drift at missense and trait-associated variants
por: Panoutsopoulou, Kalliope, et al.
Publicado: (2014)

Very low-depth sequencing in a founder population identifies a cardioprotective APOC3 signal missed by genome-wide imputation
por: Gilly, Arthur, et al.
Publicado: (2016)

Genetic Variant in the CYP19A1 Gene Associated with Coronary Artery Disease
por: Bampali, Konstantina, et al.
Publicado: (2015)

Survivin regulation by HER2 through NF-κB and c-myc in irradiated breast cancer cells
por: Papanikolaou, Vassilis, et al.
Publicado: (2011)

Validation of the Eating Habits Questionnaire in Greek adults
por: Bali, Georgia, et al.
Publicado: (2023)

Cadherin and Wnt signaling pathways as key regulators in diabetic nephropathy
por: Tziastoudi, Maria, et al.
Publicado: (2021)

MicroRNAs and the Diagnosis of Childhood Acute Lymphoblastic Leukemia: Systematic Review, Meta-Analysis and Re-Analysis with Novel Small RNA-Seq Tools
por: Kyriakidis, Ioannis, et al.
Publicado: (2022)

Evaluation of shared genetic aetiology between osteoarthritis and bone mineral density identifies SMAD3 as a novel osteoarthritis risk locus
por: Hackinger, Sophie, et al.
Publicado: (2017)

Bone morphogenetic protein-2-induced Wnt/β-catenin signaling pathway activation through enhanced low-density-lipoprotein receptor-related protein 5 catabolic activity contributes to hypertrophy in osteoarthritic chondrocytes
por: Papathanasiou, Ioanna, et al.
Publicado: (2012)

Non-coding RNAs in cancer-associated cachexia: clinical implications and future perspectives
por: Kottorou, Anastasia, et al.
Publicado: (2021)

Genome-wide meta-analysis of 92 cardiometabolic protein serum levels
por: Gilly, Arthur, et al.
Publicado: (2023)

Fondaparinux–Associated Rectus Sheath Hematoma: Skating on Thin Ice
por: Sabanis, Nikolaos, et al.
Publicado: (2020)

Central Role of SREBP-2 in the Pathogenesis of Osteoarthritis
por: Kostopoulou, Fotini, et al.
Publicado: (2012)

Widespread epigenomic, transcriptomic and proteomic differences between hip osteophytic and articular chondrocytes in osteoarthritis
por: Steinberg, Julia, et al.
Publicado: (2018)

Integrative MicroRNA and Proteomic Approaches Identify Novel Osteoarthritis Genes and Their Collaborative Metabolic and Inflammatory Networks
por: Iliopoulos, Dimitrios, et al.
Publicado: (2008)

DNA methylation regulates sclerostin (SOST) expression in osteoarthritic chondrocytes by bone morphogenetic protein 2 (BMP-2) induced changes in Smads binding affinity to the CpG region of SOST promoter
por: Papathanasiou, Ioanna, et al.
Publicado: (2015)

MicroRNA-33a regulates cholesterol synthesis and cholesterol efflux-related genes in osteoarthritic chondrocytes
por: Kostopoulou, Fotini, et al.
Publicado: (2015)

Involvement of SOX-9 and FGF-23 in RUNX-2 regulation in osteoarthritic chondrocytes
por: Orfanidou, Timoklia, et al.
Publicado: (2009)

Dual Role of SIRT1 in Autophagy and Lipid Metabolism Regulation in Osteoarthritic Chondrocytes
por: Papageorgiou, Aliki-Alexandra, et al.
Publicado: (2021)

Replication of Established Common Genetic Variants for Adult BMI and Childhood Obesity in Greek Adolescents: The TEENAGE Study
por: Ntalla, Ioanna, et al.
Publicado: (2013)

Depletion of Ras Suppressor-1 (RSU-1) promotes cell invasion of breast cancer cells through a compensatory upregulation of a truncated isoform
por: Gkretsi, Vasiliki, et al.
Publicado: (2019)

Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis
por: Zengini, Eleni, et al.
Publicado: (2018)

Using genetically isolated populations to understand the genomic basis of disease
por: Zeggini, Eleftheria
Publicado: (2014)

Eligibility and Awareness Regarding Metabolic Surgery in Patients With Type 2 Diabetes Mellitus in the Real-World Clinical Setting; Estimate of Possible Diabetes Remission
por: Koliaki, Chrysi, et al.
Publicado: (2020)

Oxidative Stress Response Is Mediated by Overexpression and Spatiotemporal Regulation of Caveolin-1
por: Goutas, Andreas, et al.
Publicado: (2020)

Neuroimaging Findings in Adolescents and Young Adults with Anorexia Nervosa: A Systematic Review
por: Kappou, Kalliopi, et al.
Publicado: (2021)

Radiographic endophenotyping in hip osteoarthritis improves the precision of genetic association analysis
por: Panoutsopoulou, Kalliope, et al.
Publicado: (2017)

Treatment of hormone positive uterine leiomyosarcoma with aromatase inhibitors
por: Thanopoulou, Eirini, et al.
Publicado: (2014)

Genome-wide association study of developmental dysplasia of the hip identifies an association with GDF5
por: Hatzikotoulas, Konstantinos, et al.
Publicado: (2018)

Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits
por: Southam, Lorraine, et al.
Publicado: (2017)

Testing for rare variant associations in complex diseases
por: Asimit, Jennifer, et al.
Publicado: (2011)

Finding common susceptibility variants for complex disease: past, present and future
por: Panoutsopoulou, Kalliope, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_egeqqalhadhl3hk38b8kkn1tga