Topoisomerase 3β interacts with RNAi machinery to promote heterochromatin formation and transcriptional silencing in Drosophila

Topoisomerases solve topological problems during DNA metabolism, but whether they participate in RNA metabolism remains unclear. Top3β represents a family of topoisomerases carrying activities for both DNA and RNA. Here we show that in Drosophila, Top3β interacts biochemically and genetically with t...

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Detalles Bibliográficos
Autores principales: Lee, Seung Kyu, Xue, Yutong, Shen, Weiping, Zhang, Yongqing, Joo, Yuyoung, Ahmad, Muzammil, Chinen, Madoka, Ding, Yi, Ku, Wai Lim, De, Supriyo, Lehrmann, Elin, Becker, Kevin G., Lei, Elissa P., Zhao, Keji, Zou, Sige, Sharov, Alexei, Wang, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251927/
https://www.ncbi.nlm.nih.gov/pubmed/30470739
http://dx.doi.org/10.1038/s41467-018-07101-4

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